The pancreatic cancer microenvironment: an immunologic battleground
Recent studies of human pancreatic cancer challenge the mouse model-derived notion that the pancreas is a site of immune privilege. A heavy infiltration of CD8+ T cells expressing programmed cell death 1 (PD-1) and smaller numbers of myeloid cells and regulatory T cells provides rationale for the cl...
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| Format: | Online |
| Language: | English |
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Taylor & Francis
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292569/ |
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pubmed-4292569 |
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pubmed-42925692015-08-03 The pancreatic cancer microenvironment: an immunologic battleground Pillarisetty, Venu G AUTHOR'S View Recent studies of human pancreatic cancer challenge the mouse model-derived notion that the pancreas is a site of immune privilege. A heavy infiltration of CD8+ T cells expressing programmed cell death 1 (PD-1) and smaller numbers of myeloid cells and regulatory T cells provides rationale for the clinical evaluation of immune checkpoint inhibition as a pancreatic cancer therapeutic strategy. Taylor & Francis 2014-08-03 /pmc/articles/PMC4292569/ /pubmed/25610740 http://dx.doi.org/10.4161/21624011.2014.950171 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Pillarisetty, Venu G |
| spellingShingle |
Pillarisetty, Venu G The pancreatic cancer microenvironment: an immunologic battleground |
| author_facet |
Pillarisetty, Venu G |
| author_sort |
Pillarisetty, Venu G |
| title |
The pancreatic cancer microenvironment: an immunologic battleground |
| title_short |
The pancreatic cancer microenvironment: an immunologic battleground |
| title_full |
The pancreatic cancer microenvironment: an immunologic battleground |
| title_fullStr |
The pancreatic cancer microenvironment: an immunologic battleground |
| title_full_unstemmed |
The pancreatic cancer microenvironment: an immunologic battleground |
| title_sort |
pancreatic cancer microenvironment: an immunologic battleground |
| description |
Recent studies of human pancreatic cancer challenge the mouse model-derived notion that the pancreas is a site of immune privilege. A heavy infiltration of CD8+ T cells expressing programmed cell death 1 (PD-1) and smaller numbers of myeloid cells and regulatory T cells provides rationale for the clinical evaluation of immune checkpoint inhibition as a pancreatic cancer therapeutic strategy. |
| publisher |
Taylor & Francis |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4292569/ |
| _version_ |
1613176142698643456 |