An injured tissue affects the opposite intact peritoneum during postoperative adhesion formation
The pathophysiology of adhesion formation needs to be clarified to reduce the adhesion-related morbidity. The epithelial characteristics of the peritoneum suggest a protective role against adhesion formation, yet how the peritoneum is involved in adhesion formation is not well characterized. We micr...
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| Format: | Online |
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Nature Publishing Group
2015
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286739/ |
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pubmed-42867392015-01-16 An injured tissue affects the opposite intact peritoneum during postoperative adhesion formation Suzuki, Tatsuya Kono, Toru Bochimoto, Hiroki Hira, Yoshiki Watanabe, Tsuyoshi Furukawa, Hiroyuki Article The pathophysiology of adhesion formation needs to be clarified to reduce the adhesion-related morbidity. The epithelial characteristics of the peritoneum suggest a protective role against adhesion formation, yet how the peritoneum is involved in adhesion formation is not well characterized. We microscopically observed an experimental model of adhesion formation to investigate the effects of an injured tissue on the opposite intact peritoneum. Adhesions were induced between injured and intact hepatic lobes, and the intact peritoneum opposite to the injured tissue was examined for 8 days. The opposite intact peritoneum was denuded of mesothelial cells for 6 hours, and the remnant mesothelial cells changed morphologically for 24 hours. The detachment of mesothelial cells allowed fibrin to attach to the basement membrane of the opposite peritoneum, connecting the two lobes. Moreover, macrophages and myofibroblasts accumulated between the two lobes, and angiogenesis occurred from the opposite intact lobe to the injured lobe. These observations indicate that an injured tissue deprives the opposite intact peritoneum of its epithelial structure and causes fibrous adhesions to the opposite intact tissue. This study implies a possible role of mesothelial cells for barrier function against adhesion formation, that is, keeping mesothelial cells intact might lead to its prophylaxis. Nature Publishing Group 2015-01-08 /pmc/articles/PMC4286739/ /pubmed/25566876 http://dx.doi.org/10.1038/srep07668 Text en Copyright © 2015, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder in order to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Suzuki, Tatsuya Kono, Toru Bochimoto, Hiroki Hira, Yoshiki Watanabe, Tsuyoshi Furukawa, Hiroyuki |
| spellingShingle |
Suzuki, Tatsuya Kono, Toru Bochimoto, Hiroki Hira, Yoshiki Watanabe, Tsuyoshi Furukawa, Hiroyuki An injured tissue affects the opposite intact peritoneum during postoperative adhesion formation |
| author_facet |
Suzuki, Tatsuya Kono, Toru Bochimoto, Hiroki Hira, Yoshiki Watanabe, Tsuyoshi Furukawa, Hiroyuki |
| author_sort |
Suzuki, Tatsuya |
| title |
An injured tissue affects the opposite intact peritoneum during postoperative adhesion formation |
| title_short |
An injured tissue affects the opposite intact peritoneum during postoperative adhesion formation |
| title_full |
An injured tissue affects the opposite intact peritoneum during postoperative adhesion formation |
| title_fullStr |
An injured tissue affects the opposite intact peritoneum during postoperative adhesion formation |
| title_full_unstemmed |
An injured tissue affects the opposite intact peritoneum during postoperative adhesion formation |
| title_sort |
injured tissue affects the opposite intact peritoneum during postoperative adhesion formation |
| description |
The pathophysiology of adhesion formation needs to be clarified to reduce the adhesion-related morbidity. The epithelial characteristics of the peritoneum suggest a protective role against adhesion formation, yet how the peritoneum is involved in adhesion formation is not well characterized. We microscopically observed an experimental model of adhesion formation to investigate the effects of an injured tissue on the opposite intact peritoneum. Adhesions were induced between injured and intact hepatic lobes, and the intact peritoneum opposite to the injured tissue was examined for 8 days. The opposite intact peritoneum was denuded of mesothelial cells for 6 hours, and the remnant mesothelial cells changed morphologically for 24 hours. The detachment of mesothelial cells allowed fibrin to attach to the basement membrane of the opposite peritoneum, connecting the two lobes. Moreover, macrophages and myofibroblasts accumulated between the two lobes, and angiogenesis occurred from the opposite intact lobe to the injured lobe. These observations indicate that an injured tissue deprives the opposite intact peritoneum of its epithelial structure and causes fibrous adhesions to the opposite intact tissue. This study implies a possible role of mesothelial cells for barrier function against adhesion formation, that is, keeping mesothelial cells intact might lead to its prophylaxis. |
| publisher |
Nature Publishing Group |
| publishDate |
2015 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4286739/ |
| _version_ |
1613174085214273536 |