Preventive Effect of TU-100 on a Type-2 Model of Colitis in Mice: Possible Involvement of Enhancing Adrenomedullin in Intestinal Epithelial Cells

by Kaneko, Atsushi, Kono, Toru, Miura, Naoko, Tsuchiya, Naoko, Yamamoto, Masahiro
Published 2013

Oxaliplatin-induced neurotoxicity involves TRPM8 in the mechanism of acute hypersensitivity to cold sensation

by Kono, Toru, Satomi, Machiko, Suno, Manabu, Kimura, Norihisa, Yamazaki, Hirotaka, Furukawa, Hiroyuki, Matsubara, Kazuo
Published 2012

Intestinal, portal, and peripheral profiles of daikenchuto (TU-100)'s active ingredients after oral administration

by Watanabe, Junko, Kaifuchi, Noriko, Kushida, Hirotaka, Matsumoto, Takashi, Fukutake, Miwako, Nishiyama, Mitsue, Yamamoto, Masahiro, Kono, Toru
Published 2015

An injured tissue affects the opposite intact peritoneum during postoperative adhesion formation

by Suzuki, Tatsuya, Kono, Toru, Bochimoto, Hiroki, Hira, Yoshiki, Watanabe, Tsuyoshi, Furukawa, Hiroyuki
Published 2015

Efficacy of Goshajinkigan for Peripheral Neurotoxicity of Oxaliplatin in Patients with Advanced or Recurrent Colorectal Cancer

by Kono, Toru, Mamiya, Noriaki, Chisato, Naoyuki, Ebisawa, Yosiaki, Yamazaki, Hirotaka, Watari, Jiro, Yamamoto, Yasuhiro, Suzuki, Shigetaka, Asama, Toshiyuki, Kamiya, Kazunori
Published 2011

Complementary and synergistic therapeutic effects of compounds found in Kampo medicine: analysis of daikenchuto

by Kono, Toru, Shimada, Mitsuo, Yamamoto, Masahiro, Kaneko, Atushi, Oomiya, Yuji, Kubota, Kunitsugu, Kase, Yoshio, Lee, Keiko, Uezono, Yasuhito
Published 2015

Double-blind, placebo-controlled, randomized phase II study of TJ-14 (Hangeshashinto) for infusional fluorinated-pyrimidine-based colorectal cancer chemotherapy-induced oral mucosi...

by Matsuda, Chu, Munemoto, Yoshinori, Mishima, Hideyuki, Nagata, Naoki, Oshiro, Mitsuru, Kataoka, Masato, Sakamoto, Junichi, Aoyama, Toru, Morita, Satoshi, Kono, Toru
Published 2015

Preventive effect of oral goshajinkigan on chronic oxaliplatin-induced hypoesthesia in rats

by Kono, Toru, Suzuki, Yasuyuki, Mizuno, Keita, Miyagi, Chika, Omiya, Yuji, Sekine, Hitomi, Mizuhara, Yasuharu, Miyano, Kanako, Kase, Yoshio, Uezono, Yasuhito
Published 2015

Hydroxy-α sanshool induces colonic motor activity in rat proximal colon: a possible involvement of KCNK9

by Kubota, Kunitsugu, Ohtake, Nobuhiro, Ohbuchi, Katsuya, Mase, Akihito, Imamura, Sachiko, Sudo, Yuka, Miyano, Kanako, Yamamoto, Masahiro, Kono, Toru, Uezono, Yasuhito
Published 2015

Goshajinkigan oxaliplatin neurotoxicity evaluation (GONE): a phase 2, multicenter, randomized, double-blind, placebo-controlled trial of goshajinkigan to prevent oxaliplatin-induce...

by Kono, Toru, Hata, Taishi, Morita, Satoshi, Munemoto, Yoshinori, Matsui, Takanori, Kojima, Hiroshi, Takemoto, Hiroyoshi, Fukunaga, Mutsumi, Nagata, Naoki, Shimada, Mitsuo, Sakamoto, Junichi, Mishima, Hideyuki
Published 2013

Double-blind, placebo-controlled, randomized phase II study of TJ-14 (hangeshashinto) for gastric cancer chemotherapy-induced oral mucositis

by Aoyama, Toru, Nishikawa, Kazuhiro, Takiguchi, Nobuhiro, Tanabe, Kazuaki, Imano, Motohiro, Fukushima, Ryoji, Sakamoto, Junichi, Oba, Mari S., Morita, Satoshi, Kono, Toru, Tsuburaya, Akira
Published 2014

TU-100 (Daikenchuto) and Ginger Ameliorate Anti-CD3 Antibody Induced T Cell-Mediated Murine Enteritis: Microbe-Independent Effects Involving Akt and NF-κB Suppression

by Ueno, Nobuhiro, Hasebe, Takumu, Kaneko, Atsushi, Yamamoto, Masahiro, Fujiya, Mikihiro, Kohgo, Yutaka, Kono, Toru, Wang, Chong-Zhi, Yuan, Chun-Su, Bissonnette, Marc, Chang, Eugene B., Musch, Mark W.
Published 2014

Metachronous pancreatic cancer originating from disseminated founder pancreatic intraductal neoplasias (PanINs)

by Imai, Koji, Karasaki, Hidenori, Ono, Yusuke, Sasajima, Junpei, Chiba, Shin‐ichi, Funakoshi, Hiroshi, Muraki, Miho, Hanaoka, Hideki, Furukawa, Takahisa, Furukawa, Hiroyuki, Kono, Toru, Nagashima, Kazuo, Mizukami, Yusuke
Published 2015

Daikenchuto (TU‐100) shapes gut microbiota architecture and increases the production of ginsenoside metabolite compound K

by Hasebe, Takumu, Ueno, Nobuhiro, Musch, Mark W., Nadimpalli, Anuradha, Kaneko, Atsushi, Kaifuchi, Noriko, Watanabe, Junko, Yamamoto, Masahiro, Kono, Toru, Inaba, Yuhei, Fujiya, Mikihiro, Kohgo, Yutaka, Chang, Eugene B.
Published 2016

Clinical efficacy of Daikenchuto for gastrointestinal dysfunction following colon surgery: a randomized, double-blind, multicenter, placebo-controlled study (JFMC39-0902)

by Katsuno, Hidetoshi, Maeda, Koutarou, Kaiho, Takashi, Kunieda, Katsuyuki, Funahashi, Kimihiko, Sakamoto, Junichi, Kono, Toru, Hasegawa, Hirotoshi, Furukawa, Yoshiyuki, Imazu, Yoshihiro, Morita, Satoshi, Watanabe, Masahiko
Published 2015

Anal Canal Adenocarcinoma in a Patient with Longstanding Crohn’s Disease Arising From Rectal Mucosa that Migrated From a Previously Treated Rectovaginal Fistula

by Maejima, Taku, Kono, Toru, Orii, Fumika, Maemoto, Atsuo, Furukawa, Shigeru, Liming, Wang, Kasai, Shoji, Fukahori, Susumu, Mukai, Nobutaka, Yoshikawa, Daitaro, Karasaki, Hidenori, Saito, Hiroya, Nagashima, Kazuo
Published 2016

Infliximab Extends the Duration until the First Surgery in Patients with Crohn's Disease

by Sakatani, Aki, Fujiya, Mikihiro, Ito, Takahiro, Inaba, Yuhei, Ueno, Nobuhiro, Kashima, Shin, Tominaga, Motoya, Moriichi, Kentaro, Okamoto, Kotaro, Tanabe, Hiroki, Ikuta, Katsuya, Ohtake, Takaaki, Kono, Toru, Furukawa, Hiroyuki, Ashida, Toshifumi, Kohgo, Yutaka
Published 2013