A 5′, 8-cyclo-2′-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase β

A 5′, 8-cyclo-2′-deoxypurine lesion induces trinucleotide repeat deletion via a unique lesion bypass by DNA polymerase β

5′,8-cyclo-2′-deoxypurines (cdPus) are common forms of oxidized DNA lesions resulting from endogenous and environmental oxidative stress such as ionizing radiation. The lesions can only be repaired by nucleotide excision repair with a low efficiency. This results in their accumulation in the genome...

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Bibliographic Details
Main Authors: Xu, Meng, Lai, Yanhao, Jiang, Zhongliang, Terzidis, Michael A., Masi, Annalisa, Chatgilialoglu, Chryssostomos, Liu, Yuan
Format: Online
Language:English
Published: Oxford University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267656/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267656/

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