Structural basis for the recognition of diastereomeric 5′,8-cyclo-2′-deoxypurine lesions by the human nucleotide excision repair system

Structural basis for the recognition of diastereomeric 5′,8-cyclo-2′-deoxypurine lesions by the human nucleotide excision repair system

The hydroxyl radical is a powerful oxidant that generates DNA lesions including the stereoisomeric R and S 5′,8-cyclo-2′-deoxyadenosine (cdA) and 5′,8-cyclo-2′-deoxyguanosine (cdG) pairs that have been detected in cellular DNA. Unlike some other oxidatively generated DNA lesions, cdG and cdA are rep...

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Bibliographic Details
Main Authors: Kropachev, Konstantin, Ding, Shuang, Terzidis, Michael A., Masi, Annalisa, Liu, Zhi, Cai, Yuqin, Kolbanovskiy, Marina, Chatgilialoglu, Chryssostomos, Broyde, Suse, Geacintov, Nicholas E., Shafirovich, Vladimir
Format: Online
Language:English
Published: Oxford University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041128/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041128/

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