Sox2-Mediated Conversion of NG2 Glia into Induced Neurons in the Injured Adult Cerebral Cortex

The adult cerebral cortex lacks the capacity to replace degenerated neurons following traumatic injury. Conversion of nonneuronal cells into induced neurons has been proposed as an innovative strategy toward brain repair. Here, we show that retrovirus-mediated expression of the transcription factors...

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Bibliographic Details
Main Authors: Heinrich, Christophe, Bergami, Matteo, Gascón, Sergio, Lepier, Alexandra, Viganò, Francesca, Dimou, Leda, Sutor, Bernd, Berninger, Benedikt, Götz, Magdalena
Format: Online
Language:English
Published: Elsevier 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264057/