Defining the role of common variation in the genomic and biological architecture of adult human height

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explain one-fifth of heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ~2,000, ~3,700 and ~9,5...

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Main Authors:	Wood, Andrew R, Esko, Tonu, Yang, Jian, Vedantam, Sailaja, Pers, Tune H, Gustafsson, Stefan, Chu, Audrey Y, Estrada, Karol, Luan, Jian’an, Kutalik, Zoltán, Amin, Najaf, Buchkovich, Martin L, Croteau-Chonka, Damien C, Day, Felix R, Duan, Yanan, Fall, Tove, Fehrmann, Rudolf, Ferreira, Teresa, Jackson, Anne U, Karjalainen, Juha, Lo, Ken Sin, Locke, Adam E, Mägi, Reedik, Mihailov, Evelin, Porcu, Eleonora, Randall, Joshua C, Scherag, André, Vinkhuyzen, Anna AE, Westra, Harm-Jan, Winkler, Thomas W, Workalemahu, Tsegaselassie, Zhao, Jing Hua, Absher, Devin, Albrecht, Eva, Anderson, Denise, Baron, Jeffrey, Beekman, Marian, Demirkan, Ayse, Ehret, Georg B, Feenstra, Bjarke, Feitosa, Mary F, Fischer, Krista, Fraser, Ross M, Goel, Anuj, Gong, Jian, Justice, Anne E, Kanoni, Stavroula, Kleber, Marcus E, Kristiansson, Kati, Lim, Unhee, Lotay, Vaneet, Lui, Julian C, Mangino, Massimo, Leach, Irene Mateo, Medina-Gomez, Carolina, Nalls, Michael A, Nyholt, Dale R, Palmer, Cameron D, Pasko, Dorota, Pechlivanis, Sonali, Prokopenko, Inga, Ried, Janina S, Ripke, Stephan, Shungin, Dmitry, Stancáková, Alena, Strawbridge, Rona J, Sung, Yun Ju, Tanaka, Toshiko, Teumer, Alexander, Trompet, Stella, van der Laan, Sander W, van Setten, Jessica, Van Vliet-Ostaptchouk, Jana V, Wang, Zhaoming, Yengo, Loïc, Zhang, Weihua, Afzal, Uzma, Ärnlöv, Johan, Arscott, Gillian M, Bandinelli, Stefania, Barrett, Amy, Bellis, Claire, Bennett, Amanda J, Berne, Christian, Blüher, Matthias, Bolton, Jennifer L, Böttcher, Yvonne, Boyd, Heather A, Bruinenberg, Marcel, Buckley, Brendan M, Buyske, Steven, Caspersen, Ida H, Chines, Peter S, Clarke, Robert, Claudi-Boehm, Simone, Cooper, Matthew, Daw, E Warwick, De Jong, Pim A, Deelen, Joris, Delgado, Graciela, Denny, Josh C, Dhonukshe-Rutten, Rosalie, Dimitriou, Maria, Doney, Alex SF, Dörr, Marcus, Eklund, Niina, Eury, Elodie, Folkersen, Lasse, Garcia, Melissa E, Geller, Frank, Giedraitis, Vilmantas, Go, Alan S, Grallert, Harald, Grammer, Tanja B, Gräßler, Jürgen, Grönberg, Henrik, de Groot, Lisette C.P.G.M., Groves, Christopher J, Haessler, Jeffrey, Hall, Per, Haller, Toomas, Hallmans, Goran, Hannemann, Anke, Hartman, Catharina A, Hassinen, Maija, Hayward, Caroline, Heard-Costa, Nancy L, Helmer, Quinta, Hemani, Gibran, Henders, Anjali K, Hillege, Hans L, Hlatky, Mark A, Hoffmann, Wolfgang, Hoffmann, Per, Holmen, Oddgeir, Houwing-Duistermaat, Jeanine J, Illig, Thomas, Isaacs, Aaron, James, Alan L, Jeff, Janina, Johansen, Berit, Johansson, Åsa, Jolley, Jennifer, Juliusdottir, Thorhildur, Junttila, Juhani, Kho, Abel N, Kinnunen, Leena, Klopp, Norman, Kocher, Thomas, Kratzer, Wolfgang, Lichtner, Peter, Lind, Lars, Lindström, Jaana, Lobbens, Stéphane, Lorentzon, Mattias, Lu, Yingchang, Lyssenko, Valeriya, Magnusson, Patrik KE, Mahajan, Anubha, Maillard, Marc, McArdle, Wendy L, McKenzie, Colin A, McLachlan, Stela, McLaren, Paul J, Menni, Cristina, Merger, Sigrun, Milani, Lili, Moayyeri, Alireza, Monda, Keri L, Morken, Mario A, Müller, Gabriele, Müller-Nurasyid, Martina, Musk, Arthur W, Narisu, Narisu, Nauck, Matthias, Nolte, Ilja M, Nöthen, Markus M, Oozageer, Laticia, Pilz, Stefan, Rayner, Nigel W, Renstrom, Frida, Robertson, Neil R, Rose, Lynda M, Roussel, Ronan, Sanna, Serena, Scharnagl, Hubert, Scholtens, Salome, Schumacher, Fredrick R, Schunkert, Heribert, Scott, Robert A, Sehmi, Joban, Seufferlein, Thomas, Shi, Jianxin, Silventoinen, Karri, Smit, Johannes H, Smith, Albert Vernon, Smolonska, Joanna, Stanton, Alice V, Stirrups, Kathleen, Stott, David J, Stringham, Heather M, Sundström, Johan, Swertz, Morris A, Syvänen, Ann-Christine, Tayo, Bamidele O, Thorleifsson, Gudmar, Tyrer, Jonathan P, van Dijk, Suzanne, van Schoor, Natasja M, van der Velde, Nathalie, van Heemst, Diana, van Oort, Floor VA, Vermeulen, Sita H, Verweij, Niek, Vonk, Judith M, Waite, Lindsay L, Waldenberger, Melanie, Wennauer, Roman, Wilkens, Lynne R, Willenborg, Christina, Wilsgaard, Tom, Wojczynski, Mary K, Wong, Andrew, Wright, Alan F, Zhang, Qunyuan, Arveiler, Dominique, Bakker, Stephan JL, Beilby, John, Bergman, Richard N, Bergmann, Sven, Biffar, Reiner, Blangero, John, Boomsma, Dorret I, Bornstein, Stefan R, Bovet, Pascal, Brambilla, Paolo, Brown, Morris J, Campbell, Harry, Caulfield, Mark J, Chakravarti, Aravinda, Collins, Rory, Collins, Francis S, Crawford, Dana C, Cupples, L Adrienne, Danesh, John, de Faire, Ulf, den Ruijter, Hester M, Erbel, Raimund, Erdmann, Jeanette, Eriksson, Johan G, Farrall, Martin, Ferrannini, Ele, Ferrières, Jean, Ford, Ian, Forouhi, Nita G, Forrester, Terrence, Gansevoort, Ron T, Gejman, Pablo V, Gieger, Christian, Golay, Alain, Gottesman, Omri, Gudnason, Vilmundur, Gyllensten, Ulf, Haas, David W, Hall, Alistair S, Harris, Tamara B, Hattersley, Andrew T, Heath, Andrew C, Hengstenberg, Christian, Hicks, Andrew A, Hindorff, Lucia A, Hingorani, Aroon D, Hofman, Albert, Hovingh, G Kees, Humphries, Steve E, Hunt, Steven C, Hypponen, Elina, Jacobs, Kevin B, Jarvelin, Marjo-Riitta, Jousilahti, Pekka, Jula, Antti M, Kaprio, Jaakko, Kastelein, John JP, Kayser, Manfred, Kee, Frank, Keinanen-Kiukaanniemi, Sirkka M, Kiemeney, Lambertus A, Kooner, Jaspal S, Kooperberg, Charles, Koskinen, Seppo, Kovacs, Peter, Kraja, Aldi T, Kumari, Meena, Kuusisto, Johanna, Lakka, Timo A, Langenberg, Claudia, Le Marchand, Loic, Lehtimäki, Terho, Lupoli, Sara, Madden, Pamela AF, Männistö, Satu, Manunta, Paolo, Marette, André, Matise, Tara C, McKnight, Barbara, Meitinger, Thomas, Moll, Frans L, Montgomery, Grant W, Morris, Andrew D, Morris, Andrew P, Murray, Jeffrey C, Nelis, Mari, Ohlsson, Claes, Oldehinkel, Albertine J, Ong, Ken K, Ouwehand, Willem H, Pasterkamp, Gerard, Peters, Annette, Pramstaller, Peter P, Price, Jackie F, Qi, Lu, Raitakari, Olli T, Rankinen, Tuomo, Rao, DC, Rice, Treva K, Ritchie, Marylyn, Rudan, Igor, Salomaa, Veikko, Samani, Nilesh J, Saramies, Jouko, Sarzynski, Mark A, Schwarz, Peter EH, Sebert, Sylvain, Sever, Peter, Shuldiner, Alan R, Sinisalo, Juha, Steinthorsdottir, Valgerdur, Stolk, Ronald P, Tardif, Jean-Claude, Tönjes, Anke, Tremblay, Angelo, Tremoli, Elena, Virtamo, Jarmo, Vohl, Marie-Claude, Amouyel, Philippe, Asselbergs, Folkert W, Assimes, Themistocles L, Bochud, Murielle, Boehm, Bernhard O, Boerwinkle, Eric, Bottinger, Erwin P, Bouchard, Claude, Cauchi, Stéphane, Chambers, John C, Chanock, Stephen J, Cooper, Richard S, de Bakker, Paul IW, Dedoussis, George, Ferrucci, Luigi, Franks, Paul W, Froguel, Philippe, Groop, Leif C, Haiman, Christopher A, Hamsten, Anders, Hayes, M Geoffrey, Hui, Jennie, Hunter, David J., Hveem, Kristian, Jukema, J Wouter, Kaplan, Robert C, Kivimaki, Mika, Kuh, Diana, Laakso, Markku, Liu, Yongmei, Martin, Nicholas G, März, Winfried, Melbye, Mads, Moebus, Susanne, Munroe, Patricia B, Njølstad, Inger, Oostra, Ben A, Palmer, Colin NA, Pedersen, Nancy L, Perola, Markus, Pérusse, Louis, Peters, Ulrike, Powell, Joseph E, Power, Chris, Quertermous, Thomas, Rauramaa, Rainer, Reinmaa, Eva, Ridker, Paul M, Rivadeneira, Fernando, Rotter, Jerome I, Saaristo, Timo E, Saleheen, Danish, Schlessinger, David, Slagboom, P Eline, Snieder, Harold, Spector, Tim D, Strauch, Konstantin, Stumvoll, Michael, Tuomilehto, Jaakko, Uusitupa, Matti, van der Harst, Pim, Völzke, Henry, Walker, Mark, Wareham, Nicholas J, Watkins, Hugh, Wichmann, H-Erich, Wilson, James F, Zanen, Pieter, Deloukas, Panos, Heid, Iris M, Lindgren, Cecilia M, Mohlke, Karen L, Speliotes, Elizabeth K, Thorsteinsdottir, Unnur, Barroso, Inês, Fox, Caroline S, North, Kari E, Strachan, David P, Beckmann, Jacques S., Berndt, Sonja I, Boehnke, Michael, Borecki, Ingrid B, McCarthy, Mark I, Metspalu, Andres, Stefansson, Kari, Uitterlinden, André G, van Duijn, Cornelia M, Franke, Lude, Willer, Cristen J, Price, Alkes L., Lettre, Guillaume, Loos, Ruth JF, Weedon, Michael N, Ingelsson, Erik, O’Connell, Jeffrey R, Abecasis, Goncalo R, Chasman, Daniel I, Goddard, Michael E, Visscher, Peter M, Hirschhorn, Joel N, Frayling, Timothy M
Format:	Online
Language:	English
Published:	2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250049/

id	pubmed-4250049
recordtype	oai_dc
spelling	pubmed-42500492015-05-01 Defining the role of common variation in the genomic and biological architecture of adult human height Wood, Andrew R Esko, Tonu Yang, Jian Vedantam, Sailaja Pers, Tune H Gustafsson, Stefan Chu, Audrey Y Estrada, Karol Luan, Jian’an Kutalik, Zoltán Amin, Najaf Buchkovich, Martin L Croteau-Chonka, Damien C Day, Felix R Duan, Yanan Fall, Tove Fehrmann, Rudolf Ferreira, Teresa Jackson, Anne U Karjalainen, Juha Lo, Ken Sin Locke, Adam E Mägi, Reedik Mihailov, Evelin Porcu, Eleonora Randall, Joshua C Scherag, André Vinkhuyzen, Anna AE Westra, Harm-Jan Winkler, Thomas W Workalemahu, Tsegaselassie Zhao, Jing Hua Absher, Devin Albrecht, Eva Anderson, Denise Baron, Jeffrey Beekman, Marian Demirkan, Ayse Ehret, Georg B Feenstra, Bjarke Feitosa, Mary F Fischer, Krista Fraser, Ross M Goel, Anuj Gong, Jian Justice, Anne E Kanoni, Stavroula Kleber, Marcus E Kristiansson, Kati Lim, Unhee Lotay, Vaneet Lui, Julian C Mangino, Massimo Leach, Irene Mateo Medina-Gomez, Carolina Nalls, Michael A Nyholt, Dale R Palmer, Cameron D Pasko, Dorota Pechlivanis, Sonali Prokopenko, Inga Ried, Janina S Ripke, Stephan Shungin, Dmitry Stancáková, Alena Strawbridge, Rona J Sung, Yun Ju Tanaka, Toshiko Teumer, Alexander Trompet, Stella van der Laan, Sander W van Setten, Jessica Van Vliet-Ostaptchouk, Jana V Wang, Zhaoming Yengo, Loïc Zhang, Weihua Afzal, Uzma Ärnlöv, Johan Arscott, Gillian M Bandinelli, Stefania Barrett, Amy Bellis, Claire Bennett, Amanda J Berne, Christian Blüher, Matthias Bolton, Jennifer L Böttcher, Yvonne Boyd, Heather A Bruinenberg, Marcel Buckley, Brendan M Buyske, Steven Caspersen, Ida H Chines, Peter S Clarke, Robert Claudi-Boehm, Simone Cooper, Matthew Daw, E Warwick De Jong, Pim A Deelen, Joris Delgado, Graciela Denny, Josh C Dhonukshe-Rutten, Rosalie Dimitriou, Maria Doney, Alex SF Dörr, Marcus Eklund, Niina Eury, Elodie Folkersen, Lasse Garcia, Melissa E Geller, Frank Giedraitis, Vilmantas Go, Alan S Grallert, Harald Grammer, Tanja B Gräßler, Jürgen Grönberg, Henrik de Groot, Lisette C.P.G.M. Groves, Christopher J Haessler, Jeffrey Hall, Per Haller, Toomas Hallmans, Goran Hannemann, Anke Hartman, Catharina A Hassinen, Maija Hayward, Caroline Heard-Costa, Nancy L Helmer, Quinta Hemani, Gibran Henders, Anjali K Hillege, Hans L Hlatky, Mark A Hoffmann, Wolfgang Hoffmann, Per Holmen, Oddgeir Houwing-Duistermaat, Jeanine J Illig, Thomas Isaacs, Aaron James, Alan L Jeff, Janina Johansen, Berit Johansson, Åsa Jolley, Jennifer Juliusdottir, Thorhildur Junttila, Juhani Kho, Abel N Kinnunen, Leena Klopp, Norman Kocher, Thomas Kratzer, Wolfgang Lichtner, Peter Lind, Lars Lindström, Jaana Lobbens, Stéphane Lorentzon, Mattias Lu, Yingchang Lyssenko, Valeriya Magnusson, Patrik KE Mahajan, Anubha Maillard, Marc McArdle, Wendy L McKenzie, Colin A McLachlan, Stela McLaren, Paul J Menni, Cristina Merger, Sigrun Milani, Lili Moayyeri, Alireza Monda, Keri L Morken, Mario A Müller, Gabriele Müller-Nurasyid, Martina Musk, Arthur W Narisu, Narisu Nauck, Matthias Nolte, Ilja M Nöthen, Markus M Oozageer, Laticia Pilz, Stefan Rayner, Nigel W Renstrom, Frida Robertson, Neil R Rose, Lynda M Roussel, Ronan Sanna, Serena Scharnagl, Hubert Scholtens, Salome Schumacher, Fredrick R Schunkert, Heribert Scott, Robert A Sehmi, Joban Seufferlein, Thomas Shi, Jianxin Silventoinen, Karri Smit, Johannes H Smith, Albert Vernon Smolonska, Joanna Stanton, Alice V Stirrups, Kathleen Stott, David J Stringham, Heather M Sundström, Johan Swertz, Morris A Syvänen, Ann-Christine Tayo, Bamidele O Thorleifsson, Gudmar Tyrer, Jonathan P van Dijk, Suzanne van Schoor, Natasja M van der Velde, Nathalie van Heemst, Diana van Oort, Floor VA Vermeulen, Sita H Verweij, Niek Vonk, Judith M Waite, Lindsay L Waldenberger, Melanie Wennauer, Roman Wilkens, Lynne R Willenborg, Christina Wilsgaard, Tom Wojczynski, Mary K Wong, Andrew Wright, Alan F Zhang, Qunyuan Arveiler, Dominique Bakker, Stephan JL Beilby, John Bergman, Richard N Bergmann, Sven Biffar, Reiner Blangero, John Boomsma, Dorret I Bornstein, Stefan R Bovet, Pascal Brambilla, Paolo Brown, Morris J Campbell, Harry Caulfield, Mark J Chakravarti, Aravinda Collins, Rory Collins, Francis S Crawford, Dana C Cupples, L Adrienne Danesh, John de Faire, Ulf den Ruijter, Hester M Erbel, Raimund Erdmann, Jeanette Eriksson, Johan G Farrall, Martin Ferrannini, Ele Ferrières, Jean Ford, Ian Forouhi, Nita G Forrester, Terrence Gansevoort, Ron T Gejman, Pablo V Gieger, Christian Golay, Alain Gottesman, Omri Gudnason, Vilmundur Gyllensten, Ulf Haas, David W Hall, Alistair S Harris, Tamara B Hattersley, Andrew T Heath, Andrew C Hengstenberg, Christian Hicks, Andrew A Hindorff, Lucia A Hingorani, Aroon D Hofman, Albert Hovingh, G Kees Humphries, Steve E Hunt, Steven C Hypponen, Elina Jacobs, Kevin B Jarvelin, Marjo-Riitta Jousilahti, Pekka Jula, Antti M Kaprio, Jaakko Kastelein, John JP Kayser, Manfred Kee, Frank Keinanen-Kiukaanniemi, Sirkka M Kiemeney, Lambertus A Kooner, Jaspal S Kooperberg, Charles Koskinen, Seppo Kovacs, Peter Kraja, Aldi T Kumari, Meena Kuusisto, Johanna Lakka, Timo A Langenberg, Claudia Le Marchand, Loic Lehtimäki, Terho Lupoli, Sara Madden, Pamela AF Männistö, Satu Manunta, Paolo Marette, André Matise, Tara C McKnight, Barbara Meitinger, Thomas Moll, Frans L Montgomery, Grant W Morris, Andrew D Morris, Andrew P Murray, Jeffrey C Nelis, Mari Ohlsson, Claes Oldehinkel, Albertine J Ong, Ken K Ouwehand, Willem H Pasterkamp, Gerard Peters, Annette Pramstaller, Peter P Price, Jackie F Qi, Lu Raitakari, Olli T Rankinen, Tuomo Rao, DC Rice, Treva K Ritchie, Marylyn Rudan, Igor Salomaa, Veikko Samani, Nilesh J Saramies, Jouko Sarzynski, Mark A Schwarz, Peter EH Sebert, Sylvain Sever, Peter Shuldiner, Alan R Sinisalo, Juha Steinthorsdottir, Valgerdur Stolk, Ronald P Tardif, Jean-Claude Tönjes, Anke Tremblay, Angelo Tremoli, Elena Virtamo, Jarmo Vohl, Marie-Claude Amouyel, Philippe Asselbergs, Folkert W Assimes, Themistocles L Bochud, Murielle Boehm, Bernhard O Boerwinkle, Eric Bottinger, Erwin P Bouchard, Claude Cauchi, Stéphane Chambers, John C Chanock, Stephen J Cooper, Richard S de Bakker, Paul IW Dedoussis, George Ferrucci, Luigi Franks, Paul W Froguel, Philippe Groop, Leif C Haiman, Christopher A Hamsten, Anders Hayes, M Geoffrey Hui, Jennie Hunter, David J. Hveem, Kristian Jukema, J Wouter Kaplan, Robert C Kivimaki, Mika Kuh, Diana Laakso, Markku Liu, Yongmei Martin, Nicholas G März, Winfried Melbye, Mads Moebus, Susanne Munroe, Patricia B Njølstad, Inger Oostra, Ben A Palmer, Colin NA Pedersen, Nancy L Perola, Markus Pérusse, Louis Peters, Ulrike Powell, Joseph E Power, Chris Quertermous, Thomas Rauramaa, Rainer Reinmaa, Eva Ridker, Paul M Rivadeneira, Fernando Rotter, Jerome I Saaristo, Timo E Saleheen, Danish Schlessinger, David Slagboom, P Eline Snieder, Harold Spector, Tim D Strauch, Konstantin Stumvoll, Michael Tuomilehto, Jaakko Uusitupa, Matti van der Harst, Pim Völzke, Henry Walker, Mark Wareham, Nicholas J Watkins, Hugh Wichmann, H-Erich Wilson, James F Zanen, Pieter Deloukas, Panos Heid, Iris M Lindgren, Cecilia M Mohlke, Karen L Speliotes, Elizabeth K Thorsteinsdottir, Unnur Barroso, Inês Fox, Caroline S North, Kari E Strachan, David P Beckmann, Jacques S. Berndt, Sonja I Boehnke, Michael Borecki, Ingrid B McCarthy, Mark I Metspalu, Andres Stefansson, Kari Uitterlinden, André G van Duijn, Cornelia M Franke, Lude Willer, Cristen J Price, Alkes L. Lettre, Guillaume Loos, Ruth JF Weedon, Michael N Ingelsson, Erik O’Connell, Jeffrey R Abecasis, Goncalo R Chasman, Daniel I Goddard, Michael E Visscher, Peter M Hirschhorn, Joel N Frayling, Timothy M Article Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explain one-fifth of heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ~2,000, ~3,700 and ~9,500 SNPs explained ~21%, ~24% and ~29% of phenotypic variance. Furthermore, all common variants together captured the majority (60%) of heritability. The 697 variants clustered in 423 loci enriched for genes, pathways, and tissue-types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/beta-catenin, and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants. 2014-10-05 2014-11 /pmc/articles/PMC4250049/ /pubmed/25282103 http://dx.doi.org/10.1038/ng.3097 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Wood, Andrew R Esko, Tonu Yang, Jian Vedantam, Sailaja Pers, Tune H Gustafsson, Stefan Chu, Audrey Y Estrada, Karol Luan, Jian’an Kutalik, Zoltán Amin, Najaf Buchkovich, Martin L Croteau-Chonka, Damien C Day, Felix R Duan, Yanan Fall, Tove Fehrmann, Rudolf Ferreira, Teresa Jackson, Anne U Karjalainen, Juha Lo, Ken Sin Locke, Adam E Mägi, Reedik Mihailov, Evelin Porcu, Eleonora Randall, Joshua C Scherag, André Vinkhuyzen, Anna AE Westra, Harm-Jan Winkler, Thomas W Workalemahu, Tsegaselassie Zhao, Jing Hua Absher, Devin Albrecht, Eva Anderson, Denise Baron, Jeffrey Beekman, Marian Demirkan, Ayse Ehret, Georg B Feenstra, Bjarke Feitosa, Mary F Fischer, Krista Fraser, Ross M Goel, Anuj Gong, Jian Justice, Anne E Kanoni, Stavroula Kleber, Marcus E Kristiansson, Kati Lim, Unhee Lotay, Vaneet Lui, Julian C Mangino, Massimo Leach, Irene Mateo Medina-Gomez, Carolina Nalls, Michael A Nyholt, Dale R Palmer, Cameron D Pasko, Dorota Pechlivanis, Sonali Prokopenko, Inga Ried, Janina S Ripke, Stephan Shungin, Dmitry Stancáková, Alena Strawbridge, Rona J Sung, Yun Ju Tanaka, Toshiko Teumer, Alexander Trompet, Stella van der Laan, Sander W van Setten, Jessica Van Vliet-Ostaptchouk, Jana V Wang, Zhaoming Yengo, Loïc Zhang, Weihua Afzal, Uzma Ärnlöv, Johan Arscott, Gillian M Bandinelli, Stefania Barrett, Amy Bellis, Claire Bennett, Amanda J Berne, Christian Blüher, Matthias Bolton, Jennifer L Böttcher, Yvonne Boyd, Heather A Bruinenberg, Marcel Buckley, Brendan M Buyske, Steven Caspersen, Ida H Chines, Peter S Clarke, Robert Claudi-Boehm, Simone Cooper, Matthew Daw, E Warwick De Jong, Pim A Deelen, Joris Delgado, Graciela Denny, Josh C Dhonukshe-Rutten, Rosalie Dimitriou, Maria Doney, Alex SF Dörr, Marcus Eklund, Niina Eury, Elodie Folkersen, Lasse Garcia, Melissa E Geller, Frank Giedraitis, Vilmantas Go, Alan S Grallert, Harald Grammer, Tanja B Gräßler, Jürgen Grönberg, Henrik de Groot, Lisette C.P.G.M. Groves, Christopher J Haessler, Jeffrey Hall, Per Haller, Toomas Hallmans, Goran Hannemann, Anke Hartman, Catharina A Hassinen, Maija Hayward, Caroline Heard-Costa, Nancy L Helmer, Quinta Hemani, Gibran Henders, Anjali K Hillege, Hans L Hlatky, Mark A Hoffmann, Wolfgang Hoffmann, Per Holmen, Oddgeir Houwing-Duistermaat, Jeanine J Illig, Thomas Isaacs, Aaron James, Alan L Jeff, Janina Johansen, Berit Johansson, Åsa Jolley, Jennifer Juliusdottir, Thorhildur Junttila, Juhani Kho, Abel N Kinnunen, Leena Klopp, Norman Kocher, Thomas Kratzer, Wolfgang Lichtner, Peter Lind, Lars Lindström, Jaana Lobbens, Stéphane Lorentzon, Mattias Lu, Yingchang Lyssenko, Valeriya Magnusson, Patrik KE Mahajan, Anubha Maillard, Marc McArdle, Wendy L McKenzie, Colin A McLachlan, Stela McLaren, Paul J Menni, Cristina Merger, Sigrun Milani, Lili Moayyeri, Alireza Monda, Keri L Morken, Mario A Müller, Gabriele Müller-Nurasyid, Martina Musk, Arthur W Narisu, Narisu Nauck, Matthias Nolte, Ilja M Nöthen, Markus M Oozageer, Laticia Pilz, Stefan Rayner, Nigel W Renstrom, Frida Robertson, Neil R Rose, Lynda M Roussel, Ronan Sanna, Serena Scharnagl, Hubert Scholtens, Salome Schumacher, Fredrick R Schunkert, Heribert Scott, Robert A Sehmi, Joban Seufferlein, Thomas Shi, Jianxin Silventoinen, Karri Smit, Johannes H Smith, Albert Vernon Smolonska, Joanna Stanton, Alice V Stirrups, Kathleen Stott, David J Stringham, Heather M Sundström, Johan Swertz, Morris A Syvänen, Ann-Christine Tayo, Bamidele O Thorleifsson, Gudmar Tyrer, Jonathan P van Dijk, Suzanne van Schoor, Natasja M van der Velde, Nathalie van Heemst, Diana van Oort, Floor VA Vermeulen, Sita H Verweij, Niek Vonk, Judith M Waite, Lindsay L Waldenberger, Melanie Wennauer, Roman Wilkens, Lynne R Willenborg, Christina Wilsgaard, Tom Wojczynski, Mary K Wong, Andrew Wright, Alan F Zhang, Qunyuan Arveiler, Dominique Bakker, Stephan JL Beilby, John Bergman, Richard N Bergmann, Sven Biffar, Reiner Blangero, John Boomsma, Dorret I Bornstein, Stefan R Bovet, Pascal Brambilla, Paolo Brown, Morris J Campbell, Harry Caulfield, Mark J Chakravarti, Aravinda Collins, Rory Collins, Francis S Crawford, Dana C Cupples, L Adrienne Danesh, John de Faire, Ulf den Ruijter, Hester M Erbel, Raimund Erdmann, Jeanette Eriksson, Johan G Farrall, Martin Ferrannini, Ele Ferrières, Jean Ford, Ian Forouhi, Nita G Forrester, Terrence Gansevoort, Ron T Gejman, Pablo V Gieger, Christian Golay, Alain Gottesman, Omri Gudnason, Vilmundur Gyllensten, Ulf Haas, David W Hall, Alistair S Harris, Tamara B Hattersley, Andrew T Heath, Andrew C Hengstenberg, Christian Hicks, Andrew A Hindorff, Lucia A Hingorani, Aroon D Hofman, Albert Hovingh, G Kees Humphries, Steve E Hunt, Steven C Hypponen, Elina Jacobs, Kevin B Jarvelin, Marjo-Riitta Jousilahti, Pekka Jula, Antti M Kaprio, Jaakko Kastelein, John JP Kayser, Manfred Kee, Frank Keinanen-Kiukaanniemi, Sirkka M Kiemeney, Lambertus A Kooner, Jaspal S Kooperberg, Charles Koskinen, Seppo Kovacs, Peter Kraja, Aldi T Kumari, Meena Kuusisto, Johanna Lakka, Timo A Langenberg, Claudia Le Marchand, Loic Lehtimäki, Terho Lupoli, Sara Madden, Pamela AF Männistö, Satu Manunta, Paolo Marette, André Matise, Tara C McKnight, Barbara Meitinger, Thomas Moll, Frans L Montgomery, Grant W Morris, Andrew D Morris, Andrew P Murray, Jeffrey C Nelis, Mari Ohlsson, Claes Oldehinkel, Albertine J Ong, Ken K Ouwehand, Willem H Pasterkamp, Gerard Peters, Annette Pramstaller, Peter P Price, Jackie F Qi, Lu Raitakari, Olli T Rankinen, Tuomo Rao, DC Rice, Treva K Ritchie, Marylyn Rudan, Igor Salomaa, Veikko Samani, Nilesh J Saramies, Jouko Sarzynski, Mark A Schwarz, Peter EH Sebert, Sylvain Sever, Peter Shuldiner, Alan R Sinisalo, Juha Steinthorsdottir, Valgerdur Stolk, Ronald P Tardif, Jean-Claude Tönjes, Anke Tremblay, Angelo Tremoli, Elena Virtamo, Jarmo Vohl, Marie-Claude Amouyel, Philippe Asselbergs, Folkert W Assimes, Themistocles L Bochud, Murielle Boehm, Bernhard O Boerwinkle, Eric Bottinger, Erwin P Bouchard, Claude Cauchi, Stéphane Chambers, John C Chanock, Stephen J Cooper, Richard S de Bakker, Paul IW Dedoussis, George Ferrucci, Luigi Franks, Paul W Froguel, Philippe Groop, Leif C Haiman, Christopher A Hamsten, Anders Hayes, M Geoffrey Hui, Jennie Hunter, David J. Hveem, Kristian Jukema, J Wouter Kaplan, Robert C Kivimaki, Mika Kuh, Diana Laakso, Markku Liu, Yongmei Martin, Nicholas G März, Winfried Melbye, Mads Moebus, Susanne Munroe, Patricia B Njølstad, Inger Oostra, Ben A Palmer, Colin NA Pedersen, Nancy L Perola, Markus Pérusse, Louis Peters, Ulrike Powell, Joseph E Power, Chris Quertermous, Thomas Rauramaa, Rainer Reinmaa, Eva Ridker, Paul M Rivadeneira, Fernando Rotter, Jerome I Saaristo, Timo E Saleheen, Danish Schlessinger, David Slagboom, P Eline Snieder, Harold Spector, Tim D Strauch, Konstantin Stumvoll, Michael Tuomilehto, Jaakko Uusitupa, Matti van der Harst, Pim Völzke, Henry Walker, Mark Wareham, Nicholas J Watkins, Hugh Wichmann, H-Erich Wilson, James F Zanen, Pieter Deloukas, Panos Heid, Iris M Lindgren, Cecilia M Mohlke, Karen L Speliotes, Elizabeth K Thorsteinsdottir, Unnur Barroso, Inês Fox, Caroline S North, Kari E Strachan, David P Beckmann, Jacques S. Berndt, Sonja I Boehnke, Michael Borecki, Ingrid B McCarthy, Mark I Metspalu, Andres Stefansson, Kari Uitterlinden, André G van Duijn, Cornelia M Franke, Lude Willer, Cristen J Price, Alkes L. Lettre, Guillaume Loos, Ruth JF Weedon, Michael N Ingelsson, Erik O’Connell, Jeffrey R Abecasis, Goncalo R Chasman, Daniel I Goddard, Michael E Visscher, Peter M Hirschhorn, Joel N Frayling, Timothy M
spellingShingle	Wood, Andrew R Esko, Tonu Yang, Jian Vedantam, Sailaja Pers, Tune H Gustafsson, Stefan Chu, Audrey Y Estrada, Karol Luan, Jian’an Kutalik, Zoltán Amin, Najaf Buchkovich, Martin L Croteau-Chonka, Damien C Day, Felix R Duan, Yanan Fall, Tove Fehrmann, Rudolf Ferreira, Teresa Jackson, Anne U Karjalainen, Juha Lo, Ken Sin Locke, Adam E Mägi, Reedik Mihailov, Evelin Porcu, Eleonora Randall, Joshua C Scherag, André Vinkhuyzen, Anna AE Westra, Harm-Jan Winkler, Thomas W Workalemahu, Tsegaselassie Zhao, Jing Hua Absher, Devin Albrecht, Eva Anderson, Denise Baron, Jeffrey Beekman, Marian Demirkan, Ayse Ehret, Georg B Feenstra, Bjarke Feitosa, Mary F Fischer, Krista Fraser, Ross M Goel, Anuj Gong, Jian Justice, Anne E Kanoni, Stavroula Kleber, Marcus E Kristiansson, Kati Lim, Unhee Lotay, Vaneet Lui, Julian C Mangino, Massimo Leach, Irene Mateo Medina-Gomez, Carolina Nalls, Michael A Nyholt, Dale R Palmer, Cameron D Pasko, Dorota Pechlivanis, Sonali Prokopenko, Inga Ried, Janina S Ripke, Stephan Shungin, Dmitry Stancáková, Alena Strawbridge, Rona J Sung, Yun Ju Tanaka, Toshiko Teumer, Alexander Trompet, Stella van der Laan, Sander W van Setten, Jessica Van Vliet-Ostaptchouk, Jana V Wang, Zhaoming Yengo, Loïc Zhang, Weihua Afzal, Uzma Ärnlöv, Johan Arscott, Gillian M Bandinelli, Stefania Barrett, Amy Bellis, Claire Bennett, Amanda J Berne, Christian Blüher, Matthias Bolton, Jennifer L Böttcher, Yvonne Boyd, Heather A Bruinenberg, Marcel Buckley, Brendan M Buyske, Steven Caspersen, Ida H Chines, Peter S Clarke, Robert Claudi-Boehm, Simone Cooper, Matthew Daw, E Warwick De Jong, Pim A Deelen, Joris Delgado, Graciela Denny, Josh C Dhonukshe-Rutten, Rosalie Dimitriou, Maria Doney, Alex SF Dörr, Marcus Eklund, Niina Eury, Elodie Folkersen, Lasse Garcia, Melissa E Geller, Frank Giedraitis, Vilmantas Go, Alan S Grallert, Harald Grammer, Tanja B Gräßler, Jürgen Grönberg, Henrik de Groot, Lisette C.P.G.M. Groves, Christopher J Haessler, Jeffrey Hall, Per Haller, Toomas Hallmans, Goran Hannemann, Anke Hartman, Catharina A Hassinen, Maija Hayward, Caroline Heard-Costa, Nancy L Helmer, Quinta Hemani, Gibran Henders, Anjali K Hillege, Hans L Hlatky, Mark A Hoffmann, Wolfgang Hoffmann, Per Holmen, Oddgeir Houwing-Duistermaat, Jeanine J Illig, Thomas Isaacs, Aaron James, Alan L Jeff, Janina Johansen, Berit Johansson, Åsa Jolley, Jennifer Juliusdottir, Thorhildur Junttila, Juhani Kho, Abel N Kinnunen, Leena Klopp, Norman Kocher, Thomas Kratzer, Wolfgang Lichtner, Peter Lind, Lars Lindström, Jaana Lobbens, Stéphane Lorentzon, Mattias Lu, Yingchang Lyssenko, Valeriya Magnusson, Patrik KE Mahajan, Anubha Maillard, Marc McArdle, Wendy L McKenzie, Colin A McLachlan, Stela McLaren, Paul J Menni, Cristina Merger, Sigrun Milani, Lili Moayyeri, Alireza Monda, Keri L Morken, Mario A Müller, Gabriele Müller-Nurasyid, Martina Musk, Arthur W Narisu, Narisu Nauck, Matthias Nolte, Ilja M Nöthen, Markus M Oozageer, Laticia Pilz, Stefan Rayner, Nigel W Renstrom, Frida Robertson, Neil R Rose, Lynda M Roussel, Ronan Sanna, Serena Scharnagl, Hubert Scholtens, Salome Schumacher, Fredrick R Schunkert, Heribert Scott, Robert A Sehmi, Joban Seufferlein, Thomas Shi, Jianxin Silventoinen, Karri Smit, Johannes H Smith, Albert Vernon Smolonska, Joanna Stanton, Alice V Stirrups, Kathleen Stott, David J Stringham, Heather M Sundström, Johan Swertz, Morris A Syvänen, Ann-Christine Tayo, Bamidele O Thorleifsson, Gudmar Tyrer, Jonathan P van Dijk, Suzanne van Schoor, Natasja M van der Velde, Nathalie van Heemst, Diana van Oort, Floor VA Vermeulen, Sita H Verweij, Niek Vonk, Judith M Waite, Lindsay L Waldenberger, Melanie Wennauer, Roman Wilkens, Lynne R Willenborg, Christina Wilsgaard, Tom Wojczynski, Mary K Wong, Andrew Wright, Alan F Zhang, Qunyuan Arveiler, Dominique Bakker, Stephan JL Beilby, John Bergman, Richard N Bergmann, Sven Biffar, Reiner Blangero, John Boomsma, Dorret I Bornstein, Stefan R Bovet, Pascal Brambilla, Paolo Brown, Morris J Campbell, Harry Caulfield, Mark J Chakravarti, Aravinda Collins, Rory Collins, Francis S Crawford, Dana C Cupples, L Adrienne Danesh, John de Faire, Ulf den Ruijter, Hester M Erbel, Raimund Erdmann, Jeanette Eriksson, Johan G Farrall, Martin Ferrannini, Ele Ferrières, Jean Ford, Ian Forouhi, Nita G Forrester, Terrence Gansevoort, Ron T Gejman, Pablo V Gieger, Christian Golay, Alain Gottesman, Omri Gudnason, Vilmundur Gyllensten, Ulf Haas, David W Hall, Alistair S Harris, Tamara B Hattersley, Andrew T Heath, Andrew C Hengstenberg, Christian Hicks, Andrew A Hindorff, Lucia A Hingorani, Aroon D Hofman, Albert Hovingh, G Kees Humphries, Steve E Hunt, Steven C Hypponen, Elina Jacobs, Kevin B Jarvelin, Marjo-Riitta Jousilahti, Pekka Jula, Antti M Kaprio, Jaakko Kastelein, John JP Kayser, Manfred Kee, Frank Keinanen-Kiukaanniemi, Sirkka M Kiemeney, Lambertus A Kooner, Jaspal S Kooperberg, Charles Koskinen, Seppo Kovacs, Peter Kraja, Aldi T Kumari, Meena Kuusisto, Johanna Lakka, Timo A Langenberg, Claudia Le Marchand, Loic Lehtimäki, Terho Lupoli, Sara Madden, Pamela AF Männistö, Satu Manunta, Paolo Marette, André Matise, Tara C McKnight, Barbara Meitinger, Thomas Moll, Frans L Montgomery, Grant W Morris, Andrew D Morris, Andrew P Murray, Jeffrey C Nelis, Mari Ohlsson, Claes Oldehinkel, Albertine J Ong, Ken K Ouwehand, Willem H Pasterkamp, Gerard Peters, Annette Pramstaller, Peter P Price, Jackie F Qi, Lu Raitakari, Olli T Rankinen, Tuomo Rao, DC Rice, Treva K Ritchie, Marylyn Rudan, Igor Salomaa, Veikko Samani, Nilesh J Saramies, Jouko Sarzynski, Mark A Schwarz, Peter EH Sebert, Sylvain Sever, Peter Shuldiner, Alan R Sinisalo, Juha Steinthorsdottir, Valgerdur Stolk, Ronald P Tardif, Jean-Claude Tönjes, Anke Tremblay, Angelo Tremoli, Elena Virtamo, Jarmo Vohl, Marie-Claude Amouyel, Philippe Asselbergs, Folkert W Assimes, Themistocles L Bochud, Murielle Boehm, Bernhard O Boerwinkle, Eric Bottinger, Erwin P Bouchard, Claude Cauchi, Stéphane Chambers, John C Chanock, Stephen J Cooper, Richard S de Bakker, Paul IW Dedoussis, George Ferrucci, Luigi Franks, Paul W Froguel, Philippe Groop, Leif C Haiman, Christopher A Hamsten, Anders Hayes, M Geoffrey Hui, Jennie Hunter, David J. Hveem, Kristian Jukema, J Wouter Kaplan, Robert C Kivimaki, Mika Kuh, Diana Laakso, Markku Liu, Yongmei Martin, Nicholas G März, Winfried Melbye, Mads Moebus, Susanne Munroe, Patricia B Njølstad, Inger Oostra, Ben A Palmer, Colin NA Pedersen, Nancy L Perola, Markus Pérusse, Louis Peters, Ulrike Powell, Joseph E Power, Chris Quertermous, Thomas Rauramaa, Rainer Reinmaa, Eva Ridker, Paul M Rivadeneira, Fernando Rotter, Jerome I Saaristo, Timo E Saleheen, Danish Schlessinger, David Slagboom, P Eline Snieder, Harold Spector, Tim D Strauch, Konstantin Stumvoll, Michael Tuomilehto, Jaakko Uusitupa, Matti van der Harst, Pim Völzke, Henry Walker, Mark Wareham, Nicholas J Watkins, Hugh Wichmann, H-Erich Wilson, James F Zanen, Pieter Deloukas, Panos Heid, Iris M Lindgren, Cecilia M Mohlke, Karen L Speliotes, Elizabeth K Thorsteinsdottir, Unnur Barroso, Inês Fox, Caroline S North, Kari E Strachan, David P Beckmann, Jacques S. Berndt, Sonja I Boehnke, Michael Borecki, Ingrid B McCarthy, Mark I Metspalu, Andres Stefansson, Kari Uitterlinden, André G van Duijn, Cornelia M Franke, Lude Willer, Cristen J Price, Alkes L. Lettre, Guillaume Loos, Ruth JF Weedon, Michael N Ingelsson, Erik O’Connell, Jeffrey R Abecasis, Goncalo R Chasman, Daniel I Goddard, Michael E Visscher, Peter M Hirschhorn, Joel N Frayling, Timothy M Defining the role of common variation in the genomic and biological architecture of adult human height
author_facet	Wood, Andrew R Esko, Tonu Yang, Jian Vedantam, Sailaja Pers, Tune H Gustafsson, Stefan Chu, Audrey Y Estrada, Karol Luan, Jian’an Kutalik, Zoltán Amin, Najaf Buchkovich, Martin L Croteau-Chonka, Damien C Day, Felix R Duan, Yanan Fall, Tove Fehrmann, Rudolf Ferreira, Teresa Jackson, Anne U Karjalainen, Juha Lo, Ken Sin Locke, Adam E Mägi, Reedik Mihailov, Evelin Porcu, Eleonora Randall, Joshua C Scherag, André Vinkhuyzen, Anna AE Westra, Harm-Jan Winkler, Thomas W Workalemahu, Tsegaselassie Zhao, Jing Hua Absher, Devin Albrecht, Eva Anderson, Denise Baron, Jeffrey Beekman, Marian Demirkan, Ayse Ehret, Georg B Feenstra, Bjarke Feitosa, Mary F Fischer, Krista Fraser, Ross M Goel, Anuj Gong, Jian Justice, Anne E Kanoni, Stavroula Kleber, Marcus E Kristiansson, Kati Lim, Unhee Lotay, Vaneet Lui, Julian C Mangino, Massimo Leach, Irene Mateo Medina-Gomez, Carolina Nalls, Michael A Nyholt, Dale R Palmer, Cameron D Pasko, Dorota Pechlivanis, Sonali Prokopenko, Inga Ried, Janina S Ripke, Stephan Shungin, Dmitry Stancáková, Alena Strawbridge, Rona J Sung, Yun Ju Tanaka, Toshiko Teumer, Alexander Trompet, Stella van der Laan, Sander W van Setten, Jessica Van Vliet-Ostaptchouk, Jana V Wang, Zhaoming Yengo, Loïc Zhang, Weihua Afzal, Uzma Ärnlöv, Johan Arscott, Gillian M Bandinelli, Stefania Barrett, Amy Bellis, Claire Bennett, Amanda J Berne, Christian Blüher, Matthias Bolton, Jennifer L Böttcher, Yvonne Boyd, Heather A Bruinenberg, Marcel Buckley, Brendan M Buyske, Steven Caspersen, Ida H Chines, Peter S Clarke, Robert Claudi-Boehm, Simone Cooper, Matthew Daw, E Warwick De Jong, Pim A Deelen, Joris Delgado, Graciela Denny, Josh C Dhonukshe-Rutten, Rosalie Dimitriou, Maria Doney, Alex SF Dörr, Marcus Eklund, Niina Eury, Elodie Folkersen, Lasse Garcia, Melissa E Geller, Frank Giedraitis, Vilmantas Go, Alan S Grallert, Harald Grammer, Tanja B Gräßler, Jürgen Grönberg, Henrik de Groot, Lisette C.P.G.M. Groves, Christopher J Haessler, Jeffrey Hall, Per Haller, Toomas Hallmans, Goran Hannemann, Anke Hartman, Catharina A Hassinen, Maija Hayward, Caroline Heard-Costa, Nancy L Helmer, Quinta Hemani, Gibran Henders, Anjali K Hillege, Hans L Hlatky, Mark A Hoffmann, Wolfgang Hoffmann, Per Holmen, Oddgeir Houwing-Duistermaat, Jeanine J Illig, Thomas Isaacs, Aaron James, Alan L Jeff, Janina Johansen, Berit Johansson, Åsa Jolley, Jennifer Juliusdottir, Thorhildur Junttila, Juhani Kho, Abel N Kinnunen, Leena Klopp, Norman Kocher, Thomas Kratzer, Wolfgang Lichtner, Peter Lind, Lars Lindström, Jaana Lobbens, Stéphane Lorentzon, Mattias Lu, Yingchang Lyssenko, Valeriya Magnusson, Patrik KE Mahajan, Anubha Maillard, Marc McArdle, Wendy L McKenzie, Colin A McLachlan, Stela McLaren, Paul J Menni, Cristina Merger, Sigrun Milani, Lili Moayyeri, Alireza Monda, Keri L Morken, Mario A Müller, Gabriele Müller-Nurasyid, Martina Musk, Arthur W Narisu, Narisu Nauck, Matthias Nolte, Ilja M Nöthen, Markus M Oozageer, Laticia Pilz, Stefan Rayner, Nigel W Renstrom, Frida Robertson, Neil R Rose, Lynda M Roussel, Ronan Sanna, Serena Scharnagl, Hubert Scholtens, Salome Schumacher, Fredrick R Schunkert, Heribert Scott, Robert A Sehmi, Joban Seufferlein, Thomas Shi, Jianxin Silventoinen, Karri Smit, Johannes H Smith, Albert Vernon Smolonska, Joanna Stanton, Alice V Stirrups, Kathleen Stott, David J Stringham, Heather M Sundström, Johan Swertz, Morris A Syvänen, Ann-Christine Tayo, Bamidele O Thorleifsson, Gudmar Tyrer, Jonathan P van Dijk, Suzanne van Schoor, Natasja M van der Velde, Nathalie van Heemst, Diana van Oort, Floor VA Vermeulen, Sita H Verweij, Niek Vonk, Judith M Waite, Lindsay L Waldenberger, Melanie Wennauer, Roman Wilkens, Lynne R Willenborg, Christina Wilsgaard, Tom Wojczynski, Mary K Wong, Andrew Wright, Alan F Zhang, Qunyuan Arveiler, Dominique Bakker, Stephan JL Beilby, John Bergman, Richard N Bergmann, Sven Biffar, Reiner Blangero, John Boomsma, Dorret I Bornstein, Stefan R Bovet, Pascal Brambilla, Paolo Brown, Morris J Campbell, Harry Caulfield, Mark J Chakravarti, Aravinda Collins, Rory Collins, Francis S Crawford, Dana C Cupples, L Adrienne Danesh, John de Faire, Ulf den Ruijter, Hester M Erbel, Raimund Erdmann, Jeanette Eriksson, Johan G Farrall, Martin Ferrannini, Ele Ferrières, Jean Ford, Ian Forouhi, Nita G Forrester, Terrence Gansevoort, Ron T Gejman, Pablo V Gieger, Christian Golay, Alain Gottesman, Omri Gudnason, Vilmundur Gyllensten, Ulf Haas, David W Hall, Alistair S Harris, Tamara B Hattersley, Andrew T Heath, Andrew C Hengstenberg, Christian Hicks, Andrew A Hindorff, Lucia A Hingorani, Aroon D Hofman, Albert Hovingh, G Kees Humphries, Steve E Hunt, Steven C Hypponen, Elina Jacobs, Kevin B Jarvelin, Marjo-Riitta Jousilahti, Pekka Jula, Antti M Kaprio, Jaakko Kastelein, John JP Kayser, Manfred Kee, Frank Keinanen-Kiukaanniemi, Sirkka M Kiemeney, Lambertus A Kooner, Jaspal S Kooperberg, Charles Koskinen, Seppo Kovacs, Peter Kraja, Aldi T Kumari, Meena Kuusisto, Johanna Lakka, Timo A Langenberg, Claudia Le Marchand, Loic Lehtimäki, Terho Lupoli, Sara Madden, Pamela AF Männistö, Satu Manunta, Paolo Marette, André Matise, Tara C McKnight, Barbara Meitinger, Thomas Moll, Frans L Montgomery, Grant W Morris, Andrew D Morris, Andrew P Murray, Jeffrey C Nelis, Mari Ohlsson, Claes Oldehinkel, Albertine J Ong, Ken K Ouwehand, Willem H Pasterkamp, Gerard Peters, Annette Pramstaller, Peter P Price, Jackie F Qi, Lu Raitakari, Olli T Rankinen, Tuomo Rao, DC Rice, Treva K Ritchie, Marylyn Rudan, Igor Salomaa, Veikko Samani, Nilesh J Saramies, Jouko Sarzynski, Mark A Schwarz, Peter EH Sebert, Sylvain Sever, Peter Shuldiner, Alan R Sinisalo, Juha Steinthorsdottir, Valgerdur Stolk, Ronald P Tardif, Jean-Claude Tönjes, Anke Tremblay, Angelo Tremoli, Elena Virtamo, Jarmo Vohl, Marie-Claude Amouyel, Philippe Asselbergs, Folkert W Assimes, Themistocles L Bochud, Murielle Boehm, Bernhard O Boerwinkle, Eric Bottinger, Erwin P Bouchard, Claude Cauchi, Stéphane Chambers, John C Chanock, Stephen J Cooper, Richard S de Bakker, Paul IW Dedoussis, George Ferrucci, Luigi Franks, Paul W Froguel, Philippe Groop, Leif C Haiman, Christopher A Hamsten, Anders Hayes, M Geoffrey Hui, Jennie Hunter, David J. Hveem, Kristian Jukema, J Wouter Kaplan, Robert C Kivimaki, Mika Kuh, Diana Laakso, Markku Liu, Yongmei Martin, Nicholas G März, Winfried Melbye, Mads Moebus, Susanne Munroe, Patricia B Njølstad, Inger Oostra, Ben A Palmer, Colin NA Pedersen, Nancy L Perola, Markus Pérusse, Louis Peters, Ulrike Powell, Joseph E Power, Chris Quertermous, Thomas Rauramaa, Rainer Reinmaa, Eva Ridker, Paul M Rivadeneira, Fernando Rotter, Jerome I Saaristo, Timo E Saleheen, Danish Schlessinger, David Slagboom, P Eline Snieder, Harold Spector, Tim D Strauch, Konstantin Stumvoll, Michael Tuomilehto, Jaakko Uusitupa, Matti van der Harst, Pim Völzke, Henry Walker, Mark Wareham, Nicholas J Watkins, Hugh Wichmann, H-Erich Wilson, James F Zanen, Pieter Deloukas, Panos Heid, Iris M Lindgren, Cecilia M Mohlke, Karen L Speliotes, Elizabeth K Thorsteinsdottir, Unnur Barroso, Inês Fox, Caroline S North, Kari E Strachan, David P Beckmann, Jacques S. Berndt, Sonja I Boehnke, Michael Borecki, Ingrid B McCarthy, Mark I Metspalu, Andres Stefansson, Kari Uitterlinden, André G van Duijn, Cornelia M Franke, Lude Willer, Cristen J Price, Alkes L. Lettre, Guillaume Loos, Ruth JF Weedon, Michael N Ingelsson, Erik O’Connell, Jeffrey R Abecasis, Goncalo R Chasman, Daniel I Goddard, Michael E Visscher, Peter M Hirschhorn, Joel N Frayling, Timothy M
author_sort	Wood, Andrew R
title	Defining the role of common variation in the genomic and biological architecture of adult human height
title_short	Defining the role of common variation in the genomic and biological architecture of adult human height
title_full	Defining the role of common variation in the genomic and biological architecture of adult human height
title_fullStr	Defining the role of common variation in the genomic and biological architecture of adult human height
title_full_unstemmed	Defining the role of common variation in the genomic and biological architecture of adult human height
title_sort	defining the role of common variation in the genomic and biological architecture of adult human height
description	Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide significance that together explain one-fifth of heritability for adult height. By testing different numbers of variants in independent studies, we show that the most strongly associated ~2,000, ~3,700 and ~9,500 SNPs explained ~21%, ~24% and ~29% of phenotypic variance. Furthermore, all common variants together captured the majority (60%) of heritability. The 697 variants clustered in 423 loci enriched for genes, pathways, and tissue-types known to be involved in growth and together implicated genes and pathways not highlighted in earlier efforts, such as signaling by fibroblast growth factors, WNT/beta-catenin, and chondroitin sulfate-related genes. We identified several genes and pathways not previously connected with human skeletal growth, including mTOR, osteoglycin and binding of hyaluronic acid. Our results indicate a genetic architecture for human height that is characterized by a very large but finite number (thousands) of causal variants.
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250049/
_version_	1613162620579217408

Defining the role of common variation in the genomic and biological architecture of adult human height

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