Analysis of microRNA transcription and post-transcriptional processing by Dicer in the context of CHO cell proliferation

Analysis of microRNA transcription and post-transcriptional processing by Dicer in the context of CHO cell proliferation

•The expression of Dicer is correlated to growth rate in different CHO cell lines.•Global perturbation of microRNA levels via DICER knockdown or overexpression directly influences CHO growth behavior.•This provides strong evidence that microRNAs are key growth regulators in CHO cell lines.

Bibliographic Details
Main Authors: Hackl, Matthias, Jadhav, Vaibhav, Klanert, Gerald, Karbiener, Michael, Scheideler, Marcel, Grillari, Johannes, Borth, Nicole
Format: Online
Language:English
Published: Elsevier Science Publishers 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247382/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247382/

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