Molecular interactions of FGF23 and PTH in phosphate regulation
Bone-derived fibroblast growth factor-23 (FGF23) plays an important role in systemic phosphate turnover. Increased FGF23 activity results in hypophosphatemic, while reduced activity is linked to hyperphosphatemic disorders. FGF23, together with klotho as co-factor, can activate FGF-receptors in its...
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| Format: | Online |
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2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246422/ |
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pubmed-42464222015-06-01 Molecular interactions of FGF23 and PTH in phosphate regulation Lanske, Beate Razzaque, Mohammed S. Article Bone-derived fibroblast growth factor-23 (FGF23) plays an important role in systemic phosphate turnover. Increased FGF23 activity results in hypophosphatemic, while reduced activity is linked to hyperphosphatemic disorders. FGF23, together with klotho as co-factor, can activate FGF-receptors in its target tissues to exert its functions. However, molecular regulation of FGF23 synthesis is not clearly defined, and recent studies have found that PTH can activate the nuclear receptor-associated protein-1 (Nurr1) to induce FGF23 transcription in bone cells. 2014-12 /pmc/articles/PMC4246422/ /pubmed/25427080 http://dx.doi.org/10.1038/ki.2014.316 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Lanske, Beate Razzaque, Mohammed S. |
| spellingShingle |
Lanske, Beate Razzaque, Mohammed S. Molecular interactions of FGF23 and PTH in phosphate regulation |
| author_facet |
Lanske, Beate Razzaque, Mohammed S. |
| author_sort |
Lanske, Beate |
| title |
Molecular interactions of FGF23 and PTH in phosphate regulation |
| title_short |
Molecular interactions of FGF23 and PTH in phosphate regulation |
| title_full |
Molecular interactions of FGF23 and PTH in phosphate regulation |
| title_fullStr |
Molecular interactions of FGF23 and PTH in phosphate regulation |
| title_full_unstemmed |
Molecular interactions of FGF23 and PTH in phosphate regulation |
| title_sort |
molecular interactions of fgf23 and pth in phosphate regulation |
| description |
Bone-derived fibroblast growth factor-23 (FGF23) plays an important role in systemic phosphate turnover. Increased FGF23 activity results in hypophosphatemic, while reduced activity is linked to hyperphosphatemic disorders. FGF23, together with klotho as co-factor, can activate FGF-receptors in its target tissues to exert its functions. However, molecular regulation of FGF23 synthesis is not clearly defined, and recent studies have found that PTH can activate the nuclear receptor-associated protein-1 (Nurr1) to induce FGF23 transcription in bone cells. |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4246422/ |
| _version_ |
1613161576627437568 |