MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines

MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines

•MycN expression correlates with TRPM7 expression in neuroblastoma (NB) tumors.•Expression of the transmembrane protein TRPM7 correlates with lower overall survival in NB tumors.•MycN promotes TRPM7 mRNA and protein expression and increases TRPM7 channel activity.•TRPM7 regulates NB cell migration.•...

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Bibliographic Details
Main Authors: Lange, Ingo, Koomoa, Dana-Lynn T.
Format: Online
Language:English
Published: Elsevier 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241534/
id pubmed-4241534
recordtype oai_dc
spelling pubmed-42415342014-11-25 MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines Lange, Ingo Koomoa, Dana-Lynn T. Article •MycN expression correlates with TRPM7 expression in neuroblastoma (NB) tumors.•Expression of the transmembrane protein TRPM7 correlates with lower overall survival in NB tumors.•MycN promotes TRPM7 mRNA and protein expression and increases TRPM7 channel activity.•TRPM7 regulates NB cell migration.•Polyamines regulate TRPM7 expression. Elsevier 2014-10-30 /pmc/articles/PMC4241534/ /pubmed/25426416 http://dx.doi.org/10.1016/j.fob.2014.10.012 Text en © 2014 The Authors http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
repository_type Open Access Journal
institution_category Foreign Institution
institution US National Center for Biotechnology Information
building NCBI PubMed
collection Online Access
language English
format Online
author Lange, Ingo
Koomoa, Dana-Lynn T.
spellingShingle Lange, Ingo
Koomoa, Dana-Lynn T.
MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines
author_facet Lange, Ingo
Koomoa, Dana-Lynn T.
author_sort Lange, Ingo
title MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines
title_short MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines
title_full MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines
title_fullStr MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines
title_full_unstemmed MycN promotes TRPM7 expression and cell migration in neuroblastoma through a process that involves polyamines
title_sort mycn promotes trpm7 expression and cell migration in neuroblastoma through a process that involves polyamines
description •MycN expression correlates with TRPM7 expression in neuroblastoma (NB) tumors.•Expression of the transmembrane protein TRPM7 correlates with lower overall survival in NB tumors.•MycN promotes TRPM7 mRNA and protein expression and increases TRPM7 channel activity.•TRPM7 regulates NB cell migration.•Polyamines regulate TRPM7 expression.
publisher Elsevier
publishDate 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4241534/
_version_ 1613159954182569984

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