Immunologic checkpoints in cancer therapy: focus on the programmed death-1 (PD-1) receptor pathway
T-lymphocytes have the potential to recognize cancer antigens as foreign and therefore eliminate them. However, immune checkpoints such as cytotoxic T-lymphocyte-associated antigen (CTLA)-4 and programmed cell death (PD)-1 receptor and its ligands (PD-L1, PD-L2) suppress the activity of T-lymphocyte...
| Main Authors: | , |
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| Format: | Online |
| Language: | English |
| Published: |
Dove Medical Press
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4238865/ |