RNA polymerase pausing and nascent RNA structure formation are linked through clamp domain movement

The rates of RNA synthesis and nascent RNA folding into biologically active structures are linked via pausing by RNA polymerase (RNAP). Structures that form within the RNA exit channel can increase pausing by interacting with bacterial RNAP or decrease pausing by preventing backtracking. Conversely,...

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Bibliographic Details
Main Authors: Hein, Pyae P., Kolb, Kellie E., Windgassen, Tricia, Bellecourt, Michael J., Darst, Seth A., Mooney, Rachel A., Landick, Robert
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156911/