Efficient transduction of LEDGF/p75 mutant cells by complementary gain-of-function HIV-1 integrase mutant viruses

Efficient transduction of LEDGF/p75 mutant cells by complementary gain-of-function HIV-1 integrase mutant viruses

Controlling the specificity of retroviral DNA integration could improve the safety of gene therapy vectors, and fusions of heterologous chromatin binding modules to the integrase (IN)–binding domain from the lentiviral integration host cofactor lens epithelium–derived growth factor (LEDGF)/p75 are a...

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Bibliographic Details
Main Authors: Wang, Hao, Shun, Ming-Chieh, Li, Xiang, Di Nunzio, Francesca, Hare, Stephen, Cherepanov, Peter, Engelman, Alan
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222252/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4222252/

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