Altered B Cell Homeostasis and Toll-Like Receptor 9-Driven Response in Type 1 Diabetes Carriers of the C1858T PTPN22 Allelic Variant: Implications in the Disease Pathogenesis

Altered B Cell Homeostasis and Toll-Like Receptor 9-Driven Response in Type 1 Diabetes Carriers of the C1858T PTPN22 Allelic Variant: Implications in the Disease Pathogenesis

Type 1 diabetes is an autoimmune disease caused by the destruction of pancreatic beta cells by autoreactive T cells. Among the genetic variants associated with type 1 diabetes, the C1858T (Lyp) polymorphism of the protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene alters the function of...

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Bibliographic Details
Main Authors: Gianchecchi, Elena, Crinò, Antonino, Giorda, Ezio, Luciano, Rosa, Perri, Valentina, Russo, Anna Lo, Cappa, Marco, Rosado, M. Manuela, Fierabracci, Alessandra
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205012/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4205012/

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