Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity?

Are APOE ɛ genotype and TOMM40 poly-T repeat length associations with cognitive ageing mediated by brain white matter tract integrity?

Genetic polymorphisms in the APOE ɛ and TOMM40 ‘523' poly-T repeat gene loci have been associated with significantly increased risk of Alzheimer's disease. This study investigated the independent effects of these polymorphisms on human cognitive ageing, and the extent to which nominally si...

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Bibliographic Details
Main Authors: Lyall, D M, Harris, S E, Bastin, M E, Muñoz Maniega, S, Murray, C, Lutz, M W, Saunders, A M, Roses, A D, Valdés Hernández, M del C, Royle, N A, Starr, J M, Porteous, D J, Wardlaw, J M, Deary, I J
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203017/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203017/

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