Clinical features of De Novo acute myeloid leukemia with concurrent DNMT3A, FLT3 and NPM1 mutations

Clinical features of De Novo acute myeloid leukemia with concurrent DNMT3A, FLT3 and NPM1 mutations

Bibliographic Details
Main Authors:	Loghavi, Sanam, Zuo, Zhuang, Ravandi, Farhad, Kantarjian, Hagop M, Bueso-Ramos, Carlos, Zhang, Liping, Singh, Rajesh R, Patel, Keyur P, Medeiros, L Jeffrey, Stingo, Francesco, Routbort, Mark, Cortes, Jorge, Luthra, Rajyalakshmi, Khoury, Joseph D
Format:	Online
Language:	English
Published:	BioMed Central 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197326/

Similar Items

FLT3, NPM1, DNMT3a and NRAS genes mutation in acute myeloid leukaemia in HUSM
by: Mat Yunus, Noraini
Published: (2015)

Mutation Analysis of JAK2V617F, FLT3-ITD, NPM1, and DNMT3A in Chinese Patients with Myeloproliferative Neoplasms
by: Wang, Min, et al.
Published: (2014)

Double inv(3)(q21q26.2) in acute myeloid leukemia is resulted from an acquired copy neutral loss of heterozygosity of chromosome 3q and associated with disease progression
by: Gu, Jun, et al.
Published: (2015)

The Addition of All-Trans Retinoic Acid to Chemotherapy May Not Improve the Outcome of Patient with NPM1 Mutated Acute Myeloid Leukemia
by: Nazha, Aziz, et al.
Published: (2013)

IDH1 and IDH2 mutations in myelodysplastic syndromes and role in disease progression
by: DiNardo, Courtney D, et al.
Published: (2015)

Screening for hotspot mutations in PI3K, JAK2, FLT3 and NPM1 in patients with myelodysplastic syndromes
by: Machado-Neto, João Agostinho, et al.
Published: (2011)

The prognostic impact of FLT3-ITD and NPM1 mutations in patients with relapsed acute myeloid leukemia and intermediate-risk cytogenetics
by: How, J, et al.
Published: (2013)

Mutation of NPM1 and FLT3 Genes in Acute Myeloid Leukemia and Their Association with Clinical and Immunophenotypic Features
by: Chauhan, Pradeep Singh, et al.
Published: (2013)

Examination of the FLT3 and NPM1 mutational status in patients with acute myeloid leukemia from southeastern Poland
by: Koczkodaj, Dorota, et al.
Published: (2016)

FLT3 and NPM-1 mutations in a cohort of acute promyelocytic leukemia patients from India
by: Swaminathan, Suchitra, et al.
Published: (2014)

Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants
by: Van Emburgh, Beth O., et al.
Published: (2011)

TP53 mutation characteristics in therapy-related myelodysplastic syndromes and acute myeloid leukemia is similar to de novo diseases
by: Ok, Chi Young, et al.
Published: (2015)

Myeloid neoplasms with isolated isochromosome 17q demonstrate a high frequency of mutations in SETBP1, SRSF2, ASXL1 and NRAS
by: Kanagal-Shamanna, Rashmi, et al.
Published: (2016)

Discovery of imatinib-responsive FIP1L1-PDGFRA mutation during refractory acute myeloid leukemia transformation of chronic myelomonocytic leukemia
by: Shah, Shilpan, et al.
Published: (2014)

DNMT1, DNMT3A and DNMT3B gene variants in relation to ovarian cancer risk in the Polish population
by: Mostowska, Adrianna, et al.
Published: (2013)

Targeted disruption of DNMT1, DNMT3A and DNMT3B in human embryonic stem cells
by: Liao, Jing, et al.
Published: (2015)

Further Activation of FLT3 Mutants by FLT3 Ligand
by: Zheng, Rui, et al.
Published: (2011)

Haemophagocytic lymphohistiocytosis occurred during induction chemotherapy in an acute monocytic leukemia patient with FLT3-ITD and DNMT3A mutations
by: Fei Li, et al.
Published: (2018-05-01)

MiR-424 and miR-155 deregulated expression in cytogenetically normal acute myeloid leukaemia: correlation with NPM1 and FLT3 mutation status
by: Faraoni, Isabella, et al.
Published: (2012)

The value of molecular stratification for CEBPA DM and NPM1 MUT FLT3 WT genotypes in older patients with acute myeloid leukaemia
by: Dickson, Glenda J., et al.
Published: (2015)

Minor BCR-ABL1-Positive Acute Myeloid Leukemia Associated With the NPM1 Mutation and FLT3 Internal Tandem Duplication
by: Kim, Moon Jung, et al.
Published: (2016)

Function of homo- and hetero-oligomers of human nucleoplasmin/nucleophosmin family proteins NPM1, NPM2 and NPM3 during sperm chromatin remodeling
by: Okuwaki, Mitsuru, et al.
Published: (2012)

Flt3 Ligand Regulates Dendritic Cell Development from Flt3+ Lymphoid and Myeloid-committed Progenitors to Flt3+ Dendritic Cells In Vivo
by: Karsunky, Holger, et al.
Published: (2003)

Dual inhibition of AKT/FLT3-ITD by A674563 overcomes FLT3 ligand-induced drug resistance in FLT3-ITD positive AML
by: Wang, Aoli, et al.
Published: (2016)

The STAT3-DNMT1 connection
by: Thomas, N. Shaun B.
Published: (2012)

Acute Myeloid Leukemia (AML) with Erythroid Predominance Exhibits Clinical and Molecular Characteristics that Differ from Other Types of AML
by: Zuo, Zhuang, et al.
Published: (2012)

FLT3 in lineage specification and plasticity
by: Greenblatt, Sarah, et al.
Published: (2012)

Determining the contribution of NPM1 heterozygosity to NPM-ALK-induced lymphomagenesis
by: McDuff, Fiona Kate Elizabeth, et al.
Published: (2011)

The development of dasatinib as a treatment for chronic myeloid leukemia (CML): from initial studies to application in newly diagnosed patients
by: Hochhaus, Andreas, et al.
Published: (2013)

Reversible Resistance Induced by FLT3 Inhibition: A Novel Resistance Mechanism in Mutant FLT3-Expressing Cells
by: Weisberg, Ellen, et al.
Published: (2011)

Inhibition of FLT3 Expression by Green Tea Catechins in FLT3 Mutated-AML Cells
by: Ly, Bui Thi Kim, et al.
Published: (2013)

FLT3 D835 Mutations Confer Differential Resistance to Type II FLT3 Inhibitors
by: Smith, Catherine C., et al.
Published: (2015)

Pim kinases modulate resistance to FLT3 tyrosine kinase inhibitors in FLT3-ITD acute myeloid leukemia
by: Green, Alexa S., et al.
Published: (2015)

Flt3/Flt3L Participates in the Process of Regulating Dendritic Cells and Regulatory T Cells in DSS-Induced Colitis
by: Mao, Jing-Wei, et al.
Published: (2014)

High DNA-methyltransferase 3B expression predicts poor outcome in acute myeloid leukemia, especially among patients with co-occurring NPM1 and FLT3 mutations
by: Monteferrario, D, et al.
Published: (2014)

Significance of DNMT3b in Oral Cancer
by: Chen, Wen-Cheng, et al.
Published: (2014)

Multivariate and subgroup analyses of a randomized, multinational, phase 3 trial of decitabine vs treatment choice of supportive care or cytarabine in older patients with newly diagnosed acute myeloid leukemia and poor- or intermediate-risk cytogenetics
by: Mayer, Jiří, et al.
Published: (2014)

Assessing impediments to NPM change
by: Peter, Steane, et al.
Published: (2015)

Survey of Activated FLT3 Signaling in Leukemia
by: Gu, Ting-lei, et al.
Published: (2011)

Abundance of Flt3 and its ligand in astrocytic tumors
by: Eßbach, C, et al.
Published: (2013)