Kinetochores require oligomerization of Dam1 complex to maintain microtubule attachments against tension and promote biorientation

Kinetochores assemble on centromeric DNA and present arrays of proteins that attach directly to the dynamic ends of microtubules. Kinetochore proteins coordinate at the microtubule interface through oligomerization, but how oligomerization contributes to kinetochore function has remained unclear. He...

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Bibliographic Details
Main Authors: Umbreit, Neil T., Miller, Matthew P., Tien, Jerry F., Cattin-Ortolá, Jérôme, Gui, Long, Lee, Kelly K., Biggins, Sue, Asbury, Charles L., Davis, Trisha N.
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197110/