Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer

Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer

Tumour cells sustain their high proliferation rate through metabolic reprogramming, whereby cellular metabolism shifts from oxidative phosphorylation to aerobic glycolysis, even under normal oxygen levels. Hypoxia-inducible factor 1A (HIF1A) is a major regulator of this process, but its activation u...

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Bibliographic Details
Main Authors: Zecchini, Vincent, Madhu, Basetti, Russell, Roslin, Pértega-Gomes, Nelma, Warren, Anne, Gaude, Edoardo, Borlido, Joana, Stark, Rory, Ireland-Zecchini, Heather, Rao, Roheet, Scott, Helen, Boren, Joan, Massie, Charlie, Asim, Mohammad, Brindle, Kevin, Griffiths, John, Frezza, Christian, Neal, David E, Mills, Ian G
Format: Online
Language:English
Published: BlackWell Publishing Ltd 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194125/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4194125/

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