Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 Complex

Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 Complex

Deficiency of autophagy protein beclin 1 is implicated in tumorigenesis and neurodegenerative diseases, but the molecular mechanism remains elusive. Previous studies showed that Beclin 1 coordinates the assembly of multiple VPS34 complexes whose distinct phosphatidylinositol 3-kinase III (PI3K-III)...

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Bibliographic Details
Main Authors: McKnight, Nicole C., Zhong, Yun, Wold, Mitchell S., Gong, Shiaoching, Phillips, Greg R., Dou, Zhixun, Zhao, Yanxiang, Heintz, Nathaniel, Zong, Wei-Xing, Yue, Zhenyu
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183436/

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