MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib

MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib

The c-MYC (MYC afterward) oncogene is well known for driving numerous oncogenic programs. However, MYC can also induce apoptosis and this function of MYC warrants further clarification. We report here that a clinically relevant proteasome inhibitor significantly increases MYC protein levels and that...

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Bibliographic Details
Main Authors: Wirth, Matthias, Stojanovic, Natasa, Christian, Jan, Paul, Mariel C., Stauber, Roland H., Schmid, Roland M., Häcker, Georg, Krämer, Oliver H., Saur, Dieter, Schneider, Günter
Format: Online
Language:English
Published: Oxford University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176343/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176343/

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