Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice

Synaptic function is modulated by LRRK2 and glutamate release is increased in cortical neurons of G2019S LRRK2 knock-in mice

Mutations in Leucine-Rich Repeat Kinase-2 (LRRK2) result in familial Parkinson's disease and the G2019S mutation alone accounts for up to 30% in some ethnicities. Despite this, the function of LRRK2 is largely undetermined although evidence suggests roles in phosphorylation, protein interaction...

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Bibliographic Details
Main Authors: Beccano-Kelly, Dayne A., Kuhlmann, Naila, Tatarnikov, Igor, Volta, Mattia, Munsie, Lise N., Chou, Patrick, Cao, Li-Ping, Han, Heather, Tapia, Lucia, Farrer, Matthew J., Milnerwood, Austen J.
Format: Online
Language:English
Published: Frontiers Media S.A. 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176085/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4176085/

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