Regulatory domain of troponin moves dynamically during activation of cardiac muscle
Heart muscle is activated by Ca2+ to generate force and shortening, and the signaling pathway involves allosteric mechanisms in the thin filament. Knowledge about the structure-function relationship among proteins in the thin filament is critical in understanding the physiology and pathology of the...
Main Authors: | Sevrieva, Ivanka, Knowles, Andrea C., Kampourakis, Thomas, Sun, Yin-Biao |
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Format: | Online |
Language: | English |
Published: |
Academic Press
2014
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Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4169182/ |
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