DNA double-strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate glioblastomas with frequent Met amplification

DNA double-strand breaks cooperate with loss of Ink4 and Arf tumor suppressors to generate glioblastomas with frequent Met amplification

Glioblastomas (GBM) are highly radioresistant and lethal brain tumors. Ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) are a risk factor for the development of GBM. In this study, we systematically examined the contribution of IR-induced DSBs to GBM development using transgenic mouse...

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Bibliographic Details
Main Authors: Camacho, Cristel V., Todorova, Pavlina K., Gillam, Molly C., Tomimatsu, Nozomi, del Alcazar, Carlos R Gil, Ilcheva, Mariya, Mukherjee, Bipasha, McEllin, Brian, Vemireddy, Vamsidhara, Hatanpaa, Kimmo, Story, Michael D., Habib, Amyn A., Murty, Vundavalli V., Bachoo, Robert, Burma, Sandeep
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167163/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167163/

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