Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice

Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice

Resection of DNA double-strand breaks (DSBs) is a pivotal step during which the choice between NHEJ and HR DNA repair pathways is made. While CDKs are known to control initiation of resection, their role in regulating long-range resection remains elusive. Here we show that CDKs 1/2 phosphorylate the...

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Bibliographic Details
Main Authors: Tomimatsu, Nozomi, Mukherjee, Bipasha, Hardebeck, Molly Catherine, Ilcheva, Mariya, Camacho, Cristel Vanessa, Harris, Janelle Louise, Porteus, Matthew, Llorente, Bertrand, Khanna, Kum Kum, Burma, Sandeep
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041212/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041212/

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