Substrate recognition of holocytochrome c synthase: N-terminal region and CXXCH motif of mitochondrial cytochrome c
•Holocytochrome c synthase (HCCS) does not attach heme to cytochromes lacking the histidine in the CXXCH motif.•HCCS can recognise C-terminally truncated cytochromes c.•The aromatic nature of, or possibly shape complementarity to, F15 in cytochrome c is important for recognition by HCCS.•The spacing...
| Main Authors: | , , |
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| Format: | Online |
| Language: | English |
| Published: |
Elsevier Science B.V
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4158909/ |
| Summary: | •Holocytochrome c synthase (HCCS) does not attach heme to cytochromes lacking the histidine in the CXXCH motif.•HCCS can recognise C-terminally truncated cytochromes c.•The aromatic nature of, or possibly shape complementarity to, F15 in cytochrome c is important for recognition by HCCS.•The spacing of the phenylalanine relative to the CXXCH is a recognition feature. |
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