Replication competent virus as an important source of bias in HIV latency models utilizing single round viral constructs

Replication competent virus as an important source of bias in HIV latency models utilizing single round viral constructs

The central memory T cell (TCM) model forms a unique HIV-1 latency model based on primary cells that closely resemble in vivo TCM. The virus employed in this model is based on an engineered vector incapable of replication after initial infection. We show that despite this strategy, replication compe...

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Bibliographic Details
Main Authors: Bonczkowski, Pawel, De Spiegelaere, Ward, Bosque, Alberto, White, Cory H, Van Nuffel, Anouk, Malatinkova, Eva, Kiselinova, Maja, Trypsteen, Wim, Witkowski, Wojciech, Vermeire, Jolien, Verhasselt, Bruno, Martins, Laura, Woelk, Christopher H, Planelles, Vicente, Vandekerckhove, Linos
Format: Online
Language:English
Published: BioMed Central 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156640/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156640/

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