Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin

Ghrelin, a brain-gut peptide that induces anxiety and other abnormal emotions, contributes to the effects of insomnia on emotional behavior. In contrast, the traditional Chinese Medicine remedy Wen Dan Tang reduces insomnia-related anxiety, which may perhaps correspond to changes in the brain-gut ax...

Full description

Bibliographic Details
Main Authors:	Wang, Liye, Song, Yuehan, Li, Feng, Liu, Yan, Ma, Jie, Mao, Meng, Wu, Fengzhi, Wu, Ying, Li, Sinai, Guan, Binghe, Liu, Xiaolan
Format:	Online
Language:	English
Published:	Medknow Publications & Media Pvt Ltd 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146165/

id	pubmed-4146165
recordtype	oai_dc
spelling	pubmed-41461652014-09-09 Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin Wang, Liye Song, Yuehan Li, Feng Liu, Yan Ma, Jie Mao, Meng Wu, Fengzhi Wu, Ying Li, Sinai Guan, Binghe Liu, Xiaolan Technical Updates Ghrelin, a brain-gut peptide that induces anxiety and other abnormal emotions, contributes to the effects of insomnia on emotional behavior. In contrast, the traditional Chinese Medicine remedy Wen Dan Tang reduces insomnia-related anxiety, which may perhaps correspond to changes in the brain-gut axis. This suggests a possible relationship between Wen Dan Tang's pharmacological mechanism and the brain-gut axis. Based on this hypothesis, a sleep-deprived rat model was induced and Wen Dan Tang was administered using oral gavage during model establishment. Wen Dan Tang significantly reduced insomnia-related anxiety and prevented Ghrelin level decreases following sleep deprivation, especially in the hypothalamus. Increased expression of Ghrelin receptor mRNA in the hypothalamus was also observed, suggesting that reduced anxiety may be a result of Wen Dan Tang's regulation of Ghrelin-Ghrelin receptors. Medknow Publications & Media Pvt Ltd 2014-01-15 /pmc/articles/PMC4146165/ /pubmed/25206802 http://dx.doi.org/10.4103/1673-5374.125351 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Wang, Liye Song, Yuehan Li, Feng Liu, Yan Ma, Jie Mao, Meng Wu, Fengzhi Wu, Ying Li, Sinai Guan, Binghe Liu, Xiaolan
spellingShingle	Wang, Liye Song, Yuehan Li, Feng Liu, Yan Ma, Jie Mao, Meng Wu, Fengzhi Wu, Ying Li, Sinai Guan, Binghe Liu, Xiaolan Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin
author_facet	Wang, Liye Song, Yuehan Li, Feng Liu, Yan Ma, Jie Mao, Meng Wu, Fengzhi Wu, Ying Li, Sinai Guan, Binghe Liu, Xiaolan
author_sort	Wang, Liye
title	Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin
title_short	Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin
title_full	Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin
title_fullStr	Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin
title_full_unstemmed	Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin
title_sort	effects of wen dan tang on insomnia-related anxiety and levels of the brain-gut peptide ghrelin
description	Ghrelin, a brain-gut peptide that induces anxiety and other abnormal emotions, contributes to the effects of insomnia on emotional behavior. In contrast, the traditional Chinese Medicine remedy Wen Dan Tang reduces insomnia-related anxiety, which may perhaps correspond to changes in the brain-gut axis. This suggests a possible relationship between Wen Dan Tang's pharmacological mechanism and the brain-gut axis. Based on this hypothesis, a sleep-deprived rat model was induced and Wen Dan Tang was administered using oral gavage during model establishment. Wen Dan Tang significantly reduced insomnia-related anxiety and prevented Ghrelin level decreases following sleep deprivation, especially in the hypothalamus. Increased expression of Ghrelin receptor mRNA in the hypothalamus was also observed, suggesting that reduced anxiety may be a result of Wen Dan Tang's regulation of Ghrelin-Ghrelin receptors.
publisher	Medknow Publications & Media Pvt Ltd
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4146165/
_version_	1613128262140035072

Effects of Wen Dan Tang on insomnia-related anxiety and levels of the brain-gut peptide Ghrelin

Similar Items