PTPN22 1858C>T gene polymorphism in patients with SLE: association with serological and clinical results

To assess the association between PTPN22 1858C>T gene polymorphism and susceptibility to, and clinical presentation of, systemic lupus erythematosus (SLE). Our study included 135 SLE patients (120 women and 15 men; mean age 45.1 years; mean course of disease from 0.5 to 31 years) and 201 healthy...

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Main Authors:	Ostanek, Lidia, Ostanek-Pańka, Magdalena, Bobrowska-Snarska, Danuta, Bińczak-Kuleta, Agnieszka, Fischer, Katarzyna, Kaczmarczyk, Mariusz, Ciechanowicz, Andrzej, Brzosko, Marek
Format:	Online
Language:	English
Published:	Springer Netherlands 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141968/

id	pubmed-4141968
recordtype	oai_dc
spelling	pubmed-41419682014-08-25 PTPN22 1858C>T gene polymorphism in patients with SLE: association with serological and clinical results Ostanek, Lidia Ostanek-Pańka, Magdalena Bobrowska-Snarska, Danuta Bińczak-Kuleta, Agnieszka Fischer, Katarzyna Kaczmarczyk, Mariusz Ciechanowicz, Andrzej Brzosko, Marek Article To assess the association between PTPN22 1858C>T gene polymorphism and susceptibility to, and clinical presentation of, systemic lupus erythematosus (SLE). Our study included 135 SLE patients (120 women and 15 men; mean age 45.1 years; mean course of disease from 0.5 to 31 years) and 201 healthy subjects. The PTPN22 1858C>T gene polymorphism was genotyped by polymerase chain reaction restriction fragment length polymorphism. A significantly higher incidence of genotype CT in patients with SLE (36.3 %) was found, compared with the control group (24.9 %). The frequencies of C1858 and T1858 alleles were 78.1 and 21.9 % in SLE patients and 86.1 and 13.9 % in controls, respectively. Significantly higher SLE susceptibility was observed in patients carrying at least one T allele (p = 0.009; OR 1.86; 95 % CI 0.14–3.05). Significant association of the PTPN22 T1858 allele (CT + TT vs.CC) and secondary antiphospholipid syndrome was observed (p = 0.049). In SLE patients carrying the T1858 allele, higher levels of antiphospholipid antibodies (anticardiolipin antibodies and/or lupus anticoagulant) were found (p = 0.030; OR 2.17; 95 % CI 1.07–4.44). Springer Netherlands 2014-07-02 2014 /pmc/articles/PMC4141968/ /pubmed/24985973 http://dx.doi.org/10.1007/s11033-014-3498-6 Text en © The Author(s) 2014 Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Ostanek, Lidia Ostanek-Pańka, Magdalena Bobrowska-Snarska, Danuta Bińczak-Kuleta, Agnieszka Fischer, Katarzyna Kaczmarczyk, Mariusz Ciechanowicz, Andrzej Brzosko, Marek
spellingShingle	Ostanek, Lidia Ostanek-Pańka, Magdalena Bobrowska-Snarska, Danuta Bińczak-Kuleta, Agnieszka Fischer, Katarzyna Kaczmarczyk, Mariusz Ciechanowicz, Andrzej Brzosko, Marek PTPN22 1858C>T gene polymorphism in patients with SLE: association with serological and clinical results
author_facet	Ostanek, Lidia Ostanek-Pańka, Magdalena Bobrowska-Snarska, Danuta Bińczak-Kuleta, Agnieszka Fischer, Katarzyna Kaczmarczyk, Mariusz Ciechanowicz, Andrzej Brzosko, Marek
author_sort	Ostanek, Lidia
title	PTPN22 1858C>T gene polymorphism in patients with SLE: association with serological and clinical results
title_short	PTPN22 1858C>T gene polymorphism in patients with SLE: association with serological and clinical results
title_full	PTPN22 1858C>T gene polymorphism in patients with SLE: association with serological and clinical results
title_fullStr	PTPN22 1858C>T gene polymorphism in patients with SLE: association with serological and clinical results
title_full_unstemmed	PTPN22 1858C>T gene polymorphism in patients with SLE: association with serological and clinical results
title_sort	ptpn22 1858c>t gene polymorphism in patients with sle: association with serological and clinical results
description	To assess the association between PTPN22 1858C>T gene polymorphism and susceptibility to, and clinical presentation of, systemic lupus erythematosus (SLE). Our study included 135 SLE patients (120 women and 15 men; mean age 45.1 years; mean course of disease from 0.5 to 31 years) and 201 healthy subjects. The PTPN22 1858C>T gene polymorphism was genotyped by polymerase chain reaction restriction fragment length polymorphism. A significantly higher incidence of genotype CT in patients with SLE (36.3 %) was found, compared with the control group (24.9 %). The frequencies of C1858 and T1858 alleles were 78.1 and 21.9 % in SLE patients and 86.1 and 13.9 % in controls, respectively. Significantly higher SLE susceptibility was observed in patients carrying at least one T allele (p = 0.009; OR 1.86; 95 % CI 0.14–3.05). Significant association of the PTPN22 T1858 allele (CT + TT vs.CC) and secondary antiphospholipid syndrome was observed (p = 0.049). In SLE patients carrying the T1858 allele, higher levels of antiphospholipid antibodies (anticardiolipin antibodies and/or lupus anticoagulant) were found (p = 0.030; OR 2.17; 95 % CI 1.07–4.44).
publisher	Springer Netherlands
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4141968/
_version_	1613126871496523776

PTPN22 1858C>T gene polymorphism in patients with SLE: association with serological and clinical results

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