Characterization and function of human Ly-6/uPAR molecules
Human Ly-6/uPAR molecules are a superfamily composed of two subfamilies; one is the membrane bound proteins with a GPI-anchor and the other are secreted proteins without the GPI-anchor. Ly-6/uPAR molecules have remarkable amino acid homology through a distinctive 8-10 cysteine-rich domain that is as...
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Korean Society for Biochemistry and Molecular Biology
2012
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133805/ |
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pubmed-4133805 |
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pubmed-41338052014-09-16 Characterization and function of human Ly-6/uPAR molecules Kong, Hyun Kyung Park, Jong Hoon Review Article Human Ly-6/uPAR molecules are a superfamily composed of two subfamilies; one is the membrane bound proteins with a GPI-anchor and the other are secreted proteins without the GPI-anchor. Ly-6/uPAR molecules have remarkable amino acid homology through a distinctive 8-10 cysteine-rich domain that is associated predominantly with O-linked glycans. These molecules are encoded by multiple tightly linked genes located on Chr. 8q23, and have a conserved genomic organization. Ly-6/uPAR molecules have an interesting expression pattern during hematopoiesis and on specific tumors indicating that Ly-6/uPAR molecules are associated with development of the immune system and carcinogenesis. Thus, Ly-6/uPAR molecules are useful antigens for diagnostic and therapeutic targets. This review summarizes our understanding of human Ly-6/uPAR molecules with regard to molecular structure as well as what is known about their function in normal and malignant tissues and suggest Ly-6/uPAR molecules as target antigens for cancer immunotherapy. [BMB Reports 2012; 45(11): 595-603] Korean Society for Biochemistry and Molecular Biology 2012-11 /pmc/articles/PMC4133805/ /pubmed/23186997 http://dx.doi.org/10.5483/BMBRep.2012.45.11.210 Text en Copyright © 2012, Korean Society for Biochemistry and Molecular Biology http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Kong, Hyun Kyung Park, Jong Hoon |
| spellingShingle |
Kong, Hyun Kyung Park, Jong Hoon Characterization and function of human Ly-6/uPAR molecules |
| author_facet |
Kong, Hyun Kyung Park, Jong Hoon |
| author_sort |
Kong, Hyun Kyung |
| title |
Characterization and function of human Ly-6/uPAR molecules |
| title_short |
Characterization and function of human Ly-6/uPAR molecules |
| title_full |
Characterization and function of human Ly-6/uPAR molecules |
| title_fullStr |
Characterization and function of human Ly-6/uPAR molecules |
| title_full_unstemmed |
Characterization and function of human Ly-6/uPAR molecules |
| title_sort |
characterization and function of human ly-6/upar molecules |
| description |
Human Ly-6/uPAR molecules are a superfamily composed of two subfamilies; one is the membrane bound proteins with a GPI-anchor and the other are secreted proteins without the GPI-anchor. Ly-6/uPAR molecules have remarkable amino acid homology through a distinctive 8-10 cysteine-rich domain that is associated predominantly with O-linked glycans. These molecules are encoded by multiple tightly linked genes located on Chr. 8q23, and have a conserved genomic organization. Ly-6/uPAR molecules have an interesting expression pattern during hematopoiesis and on specific tumors indicating that Ly-6/uPAR molecules are associated with development of the immune system and carcinogenesis. Thus, Ly-6/uPAR molecules are useful antigens for diagnostic and therapeutic targets. This review summarizes our understanding of human Ly-6/uPAR molecules with regard to molecular structure as well as what is known about their function in normal and malignant tissues and suggest Ly-6/uPAR molecules as target antigens for cancer immunotherapy. [BMB Reports 2012; 45(11): 595-603] |
| publisher |
Korean Society for Biochemistry and Molecular Biology |
| publishDate |
2012 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4133805/ |
| _version_ |
1613124621219921920 |