The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions

The PARP inhibitor Olaparib disrupts base excision repair of 5-aza-2′-deoxycytidine lesions

Decitabine (5-aza-2′-deoxycytidine, 5-azadC) is used in the treatment of Myelodysplatic syndrome (MDS) and Acute Myeloid Leukemia (AML). Its mechanism of action is thought to involve reactivation of genes implicated in differentiation and transformation, as well as induction of DNA damage by trappin...

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Bibliographic Details
Main Authors: Orta, Manuel Luis, Höglund, Andreas, Calderón-Montaño, José Manuel, Domínguez, Inmaculada, Burgos-Morón, Estefanía, Visnes, Torkild, Pastor, Nuria, Ström, Cecilia, López-lázaro, Miguel, Helleday, Thomas
Format: Online
Language:English
Published: Oxford University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132747/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4132747/

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