5-Aza-2′-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair

5-Aza-2′-deoxycytidine causes replication lesions that require Fanconi anemia-dependent homologous recombination for repair

5-Aza-2′-deoxycytidine (5-azadC) is a DNA methyltransferase (DNMT) inhibitor increasingly used in treatments of hematological diseases and works by being incorporated into DNA and trapping DNMT. It is unclear what DNA lesions are caused by 5-azadC and if such are substrates for DNA repair. Here, we...

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Bibliographic Details
Main Authors: Orta, Manuel Luís, Calderón-Montaño, José Manuel, Domínguez, Inmaculada, Pastor, Nuria, Burgos-Morón, Estefanía, López-Lázaro, Miguel, Cortés, Felipe, Mateos, Santiago, Helleday, Thomas
Format: Online
Language:English
Published: Oxford University Press 2013
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675485/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675485/

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