Bystander Activation and Anti-Tumor Effects of CD8+ T Cells Following Interleukin-2 Based Immunotherapy Is Independent of CD4+ T Cell Help

Bystander Activation and Anti-Tumor Effects of CD8+ T Cells Following Interleukin-2 Based Immunotherapy Is Independent of CD4+ T Cell Help

We have previously demonstrated that immunotherapy combining agonistic anti-CD40 and IL-2 (IT) results in synergistic anti-tumor effects. IT induces expansion of highly cytolytic, antigen-independent “bystander-activated” (CD8+CD44high) T cells displaying a CD25−NKG2D+ phenotype in a cytokine depend...

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Bibliographic Details
Main Authors: Monjazeb, Arta M., Tietze, Julia K., Grossenbacher, Steven K., Hsiao, Hui-Hua, Zamora, Anthony E., Mirsoian, Annie, Koehn, Brent, Blazar, Bruce R., Weiss, Jonathan M., Wiltrout, Robert H., Sckisel, Gail D., Murphy, William J.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131875/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4131875/

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