Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1

In a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified three novel genetic loci associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene, P = 8.82 × 10−9), rs10474352 at 5q14.3 (near th...

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Main Authors:	Cai, Qiuyin, Zhang, Ben, Sung, Hyuna, Low, Siew-Kee, Kweon, Sun-Seog, Lu, Wei, Shi, Jiajun, Long, Jirong, Wen, Wanqing, Choi, Ji-Yeob, Noh, Dong-Young, Shen, Chen-Yang, Matsuo, Keitaro, Teo, Soo-Hwang, Kim, Mi Kyung, Khoo, Ui Soon, Iwasaki, Motoki, Hartman, Mikael, Takahashi, Atsushi, Ashikawa, Kyota, Matsuda, Koichi, Shin, Min-Ho, Park, Min Ho, Zheng, Ying, Xiang, Yong-Bing, Ji, Bu-Tian, Park, Sue K., Wu, Pei-Ei, Hsiung, Chia-Ni, Ito, Hidemi, Kasuga, Yoshio, Kang, Peter, Mariapun, Shivaani, Ahn, Sei Hyun, Kang, Han Sung, Chan, Kelvin Y. K., Man, Ellen P. S., Iwata, Hiroji, Tsugane, Shoichiro, Miao, Hui, Liao, Jiemin, Nakamura, Yusuke, Kubo, Michiaki, Delahanty, Ryan J., Zhang, Yanfeng, Li, Bingshan, Li, Chun, Gao, Yu-Tang, Shu, Xiao-Ou, Kang, Daehee, Zheng, Wei
Format:	Online
Language:	English
Published:	2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127632/

id	pubmed-4127632
recordtype	oai_dc
spelling	pubmed-41276322015-02-01 Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1 Cai, Qiuyin Zhang, Ben Sung, Hyuna Low, Siew-Kee Kweon, Sun-Seog Lu, Wei Shi, Jiajun Long, Jirong Wen, Wanqing Choi, Ji-Yeob Noh, Dong-Young Shen, Chen-Yang Matsuo, Keitaro Teo, Soo-Hwang Kim, Mi Kyung Khoo, Ui Soon Iwasaki, Motoki Hartman, Mikael Takahashi, Atsushi Ashikawa, Kyota Matsuda, Koichi Shin, Min-Ho Park, Min Ho Zheng, Ying Xiang, Yong-Bing Ji, Bu-Tian Park, Sue K. Wu, Pei-Ei Hsiung, Chia-Ni Ito, Hidemi Kasuga, Yoshio Kang, Peter Mariapun, Shivaani Ahn, Sei Hyun Kang, Han Sung Chan, Kelvin Y. K. Man, Ellen P. S. Iwata, Hiroji Tsugane, Shoichiro Miao, Hui Liao, Jiemin Nakamura, Yusuke Kubo, Michiaki Delahanty, Ryan J. Zhang, Yanfeng Li, Bingshan Li, Chun Gao, Yu-Tang Shu, Xiao-Ou Kang, Daehee Zheng, Wei Article In a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified three novel genetic loci associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene, P = 8.82 × 10−9), rs10474352 at 5q14.3 (near the ARRDC3 gene, P = 1.67 × 10−9), and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene, P = 4.25 × 10−8). These associations were replicated in European-ancestry populations including 16,003 cases and 41,335 controls (P = 0.030, 0.004, and 0.010, respectively). Data from the ENCODE project suggest that variants rs4951011 and rs10474352 may be located in an enhancer region and transcription factor binding sites, respectively. This study provides additional insights into the genetics and biology of breast cancer. 2014-07-20 2014-08 /pmc/articles/PMC4127632/ /pubmed/25038754 http://dx.doi.org/10.1038/ng.3041 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Cai, Qiuyin Zhang, Ben Sung, Hyuna Low, Siew-Kee Kweon, Sun-Seog Lu, Wei Shi, Jiajun Long, Jirong Wen, Wanqing Choi, Ji-Yeob Noh, Dong-Young Shen, Chen-Yang Matsuo, Keitaro Teo, Soo-Hwang Kim, Mi Kyung Khoo, Ui Soon Iwasaki, Motoki Hartman, Mikael Takahashi, Atsushi Ashikawa, Kyota Matsuda, Koichi Shin, Min-Ho Park, Min Ho Zheng, Ying Xiang, Yong-Bing Ji, Bu-Tian Park, Sue K. Wu, Pei-Ei Hsiung, Chia-Ni Ito, Hidemi Kasuga, Yoshio Kang, Peter Mariapun, Shivaani Ahn, Sei Hyun Kang, Han Sung Chan, Kelvin Y. K. Man, Ellen P. S. Iwata, Hiroji Tsugane, Shoichiro Miao, Hui Liao, Jiemin Nakamura, Yusuke Kubo, Michiaki Delahanty, Ryan J. Zhang, Yanfeng Li, Bingshan Li, Chun Gao, Yu-Tang Shu, Xiao-Ou Kang, Daehee Zheng, Wei
spellingShingle	Cai, Qiuyin Zhang, Ben Sung, Hyuna Low, Siew-Kee Kweon, Sun-Seog Lu, Wei Shi, Jiajun Long, Jirong Wen, Wanqing Choi, Ji-Yeob Noh, Dong-Young Shen, Chen-Yang Matsuo, Keitaro Teo, Soo-Hwang Kim, Mi Kyung Khoo, Ui Soon Iwasaki, Motoki Hartman, Mikael Takahashi, Atsushi Ashikawa, Kyota Matsuda, Koichi Shin, Min-Ho Park, Min Ho Zheng, Ying Xiang, Yong-Bing Ji, Bu-Tian Park, Sue K. Wu, Pei-Ei Hsiung, Chia-Ni Ito, Hidemi Kasuga, Yoshio Kang, Peter Mariapun, Shivaani Ahn, Sei Hyun Kang, Han Sung Chan, Kelvin Y. K. Man, Ellen P. S. Iwata, Hiroji Tsugane, Shoichiro Miao, Hui Liao, Jiemin Nakamura, Yusuke Kubo, Michiaki Delahanty, Ryan J. Zhang, Yanfeng Li, Bingshan Li, Chun Gao, Yu-Tang Shu, Xiao-Ou Kang, Daehee Zheng, Wei Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1
author_facet	Cai, Qiuyin Zhang, Ben Sung, Hyuna Low, Siew-Kee Kweon, Sun-Seog Lu, Wei Shi, Jiajun Long, Jirong Wen, Wanqing Choi, Ji-Yeob Noh, Dong-Young Shen, Chen-Yang Matsuo, Keitaro Teo, Soo-Hwang Kim, Mi Kyung Khoo, Ui Soon Iwasaki, Motoki Hartman, Mikael Takahashi, Atsushi Ashikawa, Kyota Matsuda, Koichi Shin, Min-Ho Park, Min Ho Zheng, Ying Xiang, Yong-Bing Ji, Bu-Tian Park, Sue K. Wu, Pei-Ei Hsiung, Chia-Ni Ito, Hidemi Kasuga, Yoshio Kang, Peter Mariapun, Shivaani Ahn, Sei Hyun Kang, Han Sung Chan, Kelvin Y. K. Man, Ellen P. S. Iwata, Hiroji Tsugane, Shoichiro Miao, Hui Liao, Jiemin Nakamura, Yusuke Kubo, Michiaki Delahanty, Ryan J. Zhang, Yanfeng Li, Bingshan Li, Chun Gao, Yu-Tang Shu, Xiao-Ou Kang, Daehee Zheng, Wei
author_sort	Cai, Qiuyin
title	Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1
title_short	Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1
title_full	Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1
title_fullStr	Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1
title_full_unstemmed	Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1
title_sort	genome-wide association analysis in east asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1
description	In a three-stage genome-wide association study among East Asian women including 22,780 cases and 24,181 controls, we identified three novel genetic loci associated with breast cancer risk, including rs4951011 at 1q32.1 (in intron 2 of the ZC3H11A gene, P = 8.82 × 10−9), rs10474352 at 5q14.3 (near the ARRDC3 gene, P = 1.67 × 10−9), and rs2290203 at 15q26.1 (in intron 14 of the PRC1 gene, P = 4.25 × 10−8). These associations were replicated in European-ancestry populations including 16,003 cases and 41,335 controls (P = 0.030, 0.004, and 0.010, respectively). Data from the ENCODE project suggest that variants rs4951011 and rs10474352 may be located in an enhancer region and transcription factor binding sites, respectively. This study provides additional insights into the genetics and biology of breast cancer.
publishDate	2014
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4127632/
_version_	1613122796142985216

Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1

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