Differential roles of microglia and monocytes in the inflamed central nervous system

Phagocytic monocyte-derived macrophages associate with the nodes of Ranvier and initiate demyelination while microglia clear debris and display a suppressed metabolic gene signature in EAE.

Bibliographic Details
Main Authors: Yamasaki, Ryo, Lu, Haiyan, Butovsky, Oleg, Ohno, Nobuhiko, Rietsch, Anna M., Cialic, Ron, Wu, Pauline M., Doykan, Camille E., Lin, Jessica, Cotleur, Anne C., Kidd, Grahame, Zorlu, Musab M., Sun, Nathan, Hu, Weiwei, Liu, LiPing, Lee, Jar-Chi, Taylor, Sarah E., Uehlein, Lindsey, Dixon, Debra, Gu, Jinyu, Floruta, Crina M., Zhu, Min, Charo, Israel F., Weiner, Howard L., Ransohoff, Richard M.
Format: Online
Language:English
Published: The Rockefeller University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113947/