Ubiquitin Ligases in Cholesterol Metabolism
To maintain cholesterol homeostasis, the processes of cholesterol metabolism are regulated at multiple levels including transcription, translation, and enzymatic activity. Recently, the regulation of protein stability of some key players in cholesterol metabolism has been characterized. More and mor...
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Korean Diabetes Association
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083022/ |
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pubmed-40830222014-07-07 Ubiquitin Ligases in Cholesterol Metabolism Jiang, Wei Song, Bao-Liang Review To maintain cholesterol homeostasis, the processes of cholesterol metabolism are regulated at multiple levels including transcription, translation, and enzymatic activity. Recently, the regulation of protein stability of some key players in cholesterol metabolism has been characterized. More and more ubiquitin ligases have been identified including gp78, Hrd1, TRC8, TEB4, Fbw7, and inducible degrader of low density lipoprotein receptor. Their working mechanisms and physiological functions are becoming revealed. Here, we summarize the structure, substrates and function of these ubiquitin ligases. Their potential application in drug discovery is also discussed. Korean Diabetes Association 2014-06 2014-06-17 /pmc/articles/PMC4083022/ /pubmed/25003069 http://dx.doi.org/10.4093/dmj.2014.38.3.171 Text en Copyright © 2014 Korean Diabetes Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Jiang, Wei Song, Bao-Liang |
| spellingShingle |
Jiang, Wei Song, Bao-Liang Ubiquitin Ligases in Cholesterol Metabolism |
| author_facet |
Jiang, Wei Song, Bao-Liang |
| author_sort |
Jiang, Wei |
| title |
Ubiquitin Ligases in Cholesterol Metabolism |
| title_short |
Ubiquitin Ligases in Cholesterol Metabolism |
| title_full |
Ubiquitin Ligases in Cholesterol Metabolism |
| title_fullStr |
Ubiquitin Ligases in Cholesterol Metabolism |
| title_full_unstemmed |
Ubiquitin Ligases in Cholesterol Metabolism |
| title_sort |
ubiquitin ligases in cholesterol metabolism |
| description |
To maintain cholesterol homeostasis, the processes of cholesterol metabolism are regulated at multiple levels including transcription, translation, and enzymatic activity. Recently, the regulation of protein stability of some key players in cholesterol metabolism has been characterized. More and more ubiquitin ligases have been identified including gp78, Hrd1, TRC8, TEB4, Fbw7, and inducible degrader of low density lipoprotein receptor. Their working mechanisms and physiological functions are becoming revealed. Here, we summarize the structure, substrates and function of these ubiquitin ligases. Their potential application in drug discovery is also discussed. |
| publisher |
Korean Diabetes Association |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4083022/ |
| _version_ |
1613108602990493696 |