Regulation of ubiquitin ligase dynamics by the nucleolus

Cellular pathways relay information through dynamic protein interactions. We have assessed the kinetic properties of the murine double minute protein (MDM2) and von Hippel-Lindau (VHL) ubiquitin ligases in living cells under physiological conditions that alter the stability of their respective p53 a...

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Bibliographic Details
Main Authors: Mekhail, Karim, Khacho, Mireille, Carrigan, Amanda, Hache, Robert R.J., Gunaratnam, Lakshman, Lee, Stephen
Format: Online
Language:English
Published: The Rockefeller University Press 2005
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2171338/