The Machinery at Endoplasmic Reticulum-Plasma Membrane Contact Sites Contributes to Spatial Regulation of Multiple Legionella Effector Proteins

The Dot/Icm system of the intracellular pathogen Legionella pneumophila has the capacity to deliver over 270 effector proteins into host cells during infection. Important questions remain as to spatial and temporal mechanisms used to regulate such a large array of virulence determinants after they h...

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Bibliographic Details
Main Authors: Hubber, Andree, Arasaki, Kohei, Nakatsu, Fubito, Hardiman, Camille, Lambright, David, De Camilli, Pietro, Nagai, Hiroki, Roy, Craig R.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081824/