Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling

Lysosomal-mediated waste clearance in retinal pigment epithelial cells is regulated by CRYBA1/βA3/A1-crystallin via V-ATPase-MTORC1 signaling

In phagocytic cells, including the retinal pigment epithelium (RPE), acidic compartments of the endolysosomal system are regulators of both phagocytosis and autophagy, thereby helping to maintain cellular homeostasis. The acidification of the endolysosomal system is modulated by a proton pump, the V...

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Bibliographic Details
Main Authors: Valapala, Mallika, Wilson, Christine, Hose, Stacey, Bhutto, Imran A, Grebe, Rhonda, Dong, Aling, Greenbaum, Seth, Gu, Limin, Sengupta, Samhita, Cano, Marisol, Hackett, Sean, Xu, Guotong, Lutty, Gerard A, Dong, Lijin, Sergeev, Yuri, Handa, James T, Campochiaro, Peter, Wawrousek, Eric, Zigler, Jr, J Samuel, Sinha, Debasish
Format: Online
Language:English
Published: Landes Bioscience 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077886/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4077886/

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