The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity

The Wnt Receptor Ryk Reduces Neuronal and Cell Survival Capacity by Repressing FOXO Activity During the Early Phases of Mutant Huntingtin Pathogenicity

A study of Huntington's disease reveals that neurons might fail to cope with maintaining their function during the pre-symptomatic, pathogenic phases of HD, possibly due to the early repression of key longevity-promoting transcription factors by abnormal developmental signaling.

Bibliographic Details
Main Authors: Tourette, Cendrine, Farina, Francesca, Vazquez-Manrique, Rafael P., Orfila, Anne-Marie, Voisin, Jessica, Hernandez, Sonia, Offner, Nicolas, Parker, J. Alex, Menet, Sophie, Kim, Jinho, Lyu, Jungmok, Choi, Si Ho, Cormier, Kerry, Edgerly, Christina K., Bordiuk, Olivia L., Smith, Karen, Louise, Anne, Halford, Michael, Stacker, Steven, Vert, Jean-Philippe, Ferrante, Robert J., Lu, Wange, Neri, Christian
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068980/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068980/

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