Neuronal Targets of Mutant Huntingtin Genetic Reduction to Ameliorate Huntington’s Disease Pathogenesis in Mice

Neuronal Targets of Mutant Huntingtin Genetic Reduction to Ameliorate Huntington’s Disease Pathogenesis in Mice

Huntington’s disease (HD) is a fatal dominantly inherited neurodegenerative disorder caused by a CAG repeat expansion leading to an elongated polyglutamine stretch in Huntingtin1. Mutant Huntingtin (mHTT) is ubiquitously expressed but elicits selective cortical and striatal neurodegeneration in HD2....

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Bibliographic Details
Main Authors: Wang, Nan, Gray, Michelle, Lu, Xiao-Hong, Cantle, Jeffrey P., Holley, Sandra M., Greiner, Erin, Gu, Xiaofeng, Shirasaki, Dyna, Cepeda, Carlos, Li, Yuqing, Dong, Hongwei, Levine, Michael S., Yang, X. William
Format: Online
Language:English
Published: 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067603/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4067603/

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