Large scale analysis of signal reachability
Motivation: Major disorders, such as leukemia, have been shown to alter the transcription of genes. Understanding how gene regulation is affected by such aberrations is of utmost importance. One promising strategy toward this objective is to compute whether signals can reach to the transcription fac...
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| Format: | Online |
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Oxford University Press
2014
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058948/ |
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pubmed-40589482014-06-18 Large scale analysis of signal reachability Todor, Andrei Gabr, Haitham Dobra, Alin Kahveci, Tamer Ismb 2014 Proceedings Papers Committee Motivation: Major disorders, such as leukemia, have been shown to alter the transcription of genes. Understanding how gene regulation is affected by such aberrations is of utmost importance. One promising strategy toward this objective is to compute whether signals can reach to the transcription factors through the transcription regulatory network (TRN). Due to the uncertainty of the regulatory interactions, this is a #P-complete problem and thus solving it for very large TRNs remains to be a challenge. Oxford University Press 2014-06-15 2014-06-11 /pmc/articles/PMC4058948/ /pubmed/24932011 http://dx.doi.org/10.1093/bioinformatics/btu262 Text en © The Author 2014. Published by Oxford University Press. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contactjournals.permissions@oup.com. |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Todor, Andrei Gabr, Haitham Dobra, Alin Kahveci, Tamer |
| spellingShingle |
Todor, Andrei Gabr, Haitham Dobra, Alin Kahveci, Tamer Large scale analysis of signal reachability |
| author_facet |
Todor, Andrei Gabr, Haitham Dobra, Alin Kahveci, Tamer |
| author_sort |
Todor, Andrei |
| title |
Large scale analysis of signal reachability |
| title_short |
Large scale analysis of signal reachability |
| title_full |
Large scale analysis of signal reachability |
| title_fullStr |
Large scale analysis of signal reachability |
| title_full_unstemmed |
Large scale analysis of signal reachability |
| title_sort |
large scale analysis of signal reachability |
| description |
Motivation: Major disorders, such as leukemia, have been shown to alter the transcription of genes. Understanding how gene regulation is affected by such aberrations is of utmost importance. One promising strategy toward this objective is to compute whether signals can reach to the transcription factors through the transcription regulatory network (TRN). Due to the uncertainty of the regulatory interactions, this is a #P-complete problem and thus solving it for very large TRNs remains to be a challenge. |
| publisher |
Oxford University Press |
| publishDate |
2014 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058948/ |
| _version_ |
1612101880750538752 |