Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole–imidazole polyamide, which targets an E-box motif

Inhibition of malignant phenotypes of human osteosarcoma cells by a gene silencer, a pyrrole–imidazole polyamide, which targets an E-box motif

•We generated pyrrole–imidazole (PI) polyamides that could bind to an E-box motif.•PI polyamide Myc-6 induces G1 arrest and apoptosis in human osteosarcoma MG63 cells.•Myc-6 represses tumor growth both in vitro and in vivo.•Myc-6 binds to the 5′-upstream region of noncoding RNA MALAT1 and reduces it...

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Bibliographic Details
Main Authors: Taniguchi, Masashi, Fujiwara, Kyoko, Nakai, Yuji, Ozaki, Toshinori, Koshikawa, Nobuko, Toshio, Kojima, Kataba, Motoaki, Oguni, Asako, Matsuda, Hiroyuki, Yoshida, Yukihiro, Tokuhashi, Yasuaki, Fukuda, Noboru, Ueno, Takahiro, Soma, Masayoshi, Nagase, Hiroki
Format: Online
Language:English
Published: Elsevier 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048845/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048845/

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