Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells

Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells

Lymphangioleiomyomatosis (LAM) is a female-predominant interstitial lung disease that can lead to respiratory failure. LAM cells typically have inactivating TSC2 mutations, leading to mTORC1 activation. The gender specificity of LAM suggests that estradiol contributes to disease development, yet the...

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Bibliographic Details
Main Authors: Sun, Y, Gu, X, Zhang, E, Park, M-A, Pereira, A M, Wang, S, Morrison, T, Li, C, Blenis, J, Gerbaudo, V H, Henske, E P, Yu, J J
Format: Online
Language:English
Published: Nature Publishing Group 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047866/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4047866/

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