Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells

Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells

Estradiol enhances COX-2 expression and prostaglandin biosynthesis in TSC2-deficient cells via a rapamycin-insensitive, mTORC2-dependent mechanism.

Bibliographic Details
Main Authors: Li, Chenggang, Lee, Po-Shun, Sun, Yang, Gu, Xiaoxiao, Zhang, Erik, Guo, Yanan, Wu, Chin-Lee, Auricchio, Neil, Priolo, Carmen, Li, Jing, Csibi, Alfredo, Parkhitko, Andrey, Morrison, Tasha, Planaguma, Anna, Kazani, Shamsah, Israel, Elliot, Xu, Kai-Feng, Henske, Elizabeth Petri, Blenis, John, Levy, Bruce D., Kwiatkowski, David, Yu, Jane J.
Format: Online
Language:English
Published: The Rockefeller University Press 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892971/

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3892971/

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