Small molecule compounds targeting the p53 pathway: are we finally making progress?

Loss of function of p53, either through mutations in the gene or through mutations to other members of the pathway that inactivate wild-type p53, remains a critically important aspect of human cancer development. As such, p53 remains the most commonly mutated gene in human cancer. For these reasons...

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Bibliographic Details
Main Authors: Yu, Xin, Narayanan, Sumana, Vazquez, Alexei, Carpizo, Darren R.
Format: Online
Language:English
Published: Springer US 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4039992/