| Summary: | Extracorporeal membrane oxygenation can potentially affect cerebral blood flow
dynamics and consequently influence cerebral autoregulation. We applied wavelet
cross-correlation (WCC) between multichannel cerebral oxyhemoglobin concentration
(HbO2) and mean arterial pressure (MAP), to assess regional
variations in cerebral autoregulation. Six infants on veno-arterial (VA) ECMO were
studied during sequential changes in the ECMO flows. WCC between MAP and
HbO2 for each flow period and each channel was calculated
within three different frequency (wavelet scale) bands centered around 0.1, 0.16, and
0.3 Hz chosen to represent low frequency oscillations, ventilation, and respiration
rates, respectively. The group data showed a relationship between maximum WCC and ECMO
flow. During changes in ECMO flow, statistically significant differences in maximum
WCC were found between right and left hemispheres. WCC between
HbO2 and MAP provides a useful method to investigate the
dynamics of cerebral autoregulation during ECMO. Manipulations of ECMO flows are
associated with regional changes in cerebral autoregulation which may potentially have
an important bearing on clinical outcome.
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