Acid-Sensing Ion Channels and Pain
Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels (ASICs) are proton-gated cation channels expressed in both central and peripheral nervous systems. Increasing evidence su...
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| Format: | Online |
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MDPI
2010
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033989/ |
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pubmed-4033989 |
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pubmed-40339892014-05-27 Acid-Sensing Ion Channels and Pain Gu, Qihai Lee, Lu-Yuan Review Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels (ASICs) are proton-gated cation channels expressed in both central and peripheral nervous systems. Increasing evidence suggests that ASICs represent essential sensors for tissue acidosis-related pain. This review provides an update on the role of ASICs in pain sensation and discusses their therapeutic potential for pain management. MDPI 2010-05-11 /pmc/articles/PMC4033989/ /pubmed/27713310 http://dx.doi.org/10.3390/ph3051411 Text en © 2010 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| repository_type |
Open Access Journal |
| institution_category |
Foreign Institution |
| institution |
US National Center for Biotechnology Information |
| building |
NCBI PubMed |
| collection |
Online Access |
| language |
English |
| format |
Online |
| author |
Gu, Qihai Lee, Lu-Yuan |
| spellingShingle |
Gu, Qihai Lee, Lu-Yuan Acid-Sensing Ion Channels and Pain |
| author_facet |
Gu, Qihai Lee, Lu-Yuan |
| author_sort |
Gu, Qihai |
| title |
Acid-Sensing Ion Channels and Pain |
| title_short |
Acid-Sensing Ion Channels and Pain |
| title_full |
Acid-Sensing Ion Channels and Pain |
| title_fullStr |
Acid-Sensing Ion Channels and Pain |
| title_full_unstemmed |
Acid-Sensing Ion Channels and Pain |
| title_sort |
acid-sensing ion channels and pain |
| description |
Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis. Acid sensing ion channels (ASICs) are proton-gated cation channels expressed in both central and peripheral nervous systems. Increasing evidence suggests that ASICs represent essential sensors for tissue acidosis-related pain. This review provides an update on the role of ASICs in pain sensation and discusses their therapeutic potential for pain management. |
| publisher |
MDPI |
| publishDate |
2010 |
| url |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4033989/ |
| _version_ |
1612093427353124864 |