Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2

Molecular mechanism of Aurora A kinase autophosphorylation and its allosteric activation by TPX2

We elucidate the molecular mechanisms of two distinct activation strategies (autophosphorylation and TPX2-mediated activation) in human Aurora A kinase. Classic allosteric activation is in play where either activation loop phosphorylation or TPX2 binding to a conserved hydrophobic groove shifts the...

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Bibliographic Details
Main Authors:	Zorba, Adelajda, Buosi, Vanessa, Kutter, Steffen, Kern, Nadja, Pontiggia, Francesco, Cho, Young-Jin, Kern, Dorothee
Format:	Online
Language:	English
Published:	eLife Sciences Publications, Ltd 2014
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032492/

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