High glucose impairs the proliferation and increases the apoptosis of endothelial progenitor cells by suppression of Akt

Aims/Introduction: Endothelial progenitor cells (EPC) play a critical role in adult vasculogenesis and vascular repair. Previous studies have described the dysfunction of EPC in diabetic patients, but the precise mechanism is still unclear. To elucidate the dysfunction of EPC in diabetic patients,...

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Main Authors:	Nakamura, Nobuhisa, Naruse, Keiko, Kobayashi, Yasuko, Matsuki, Takashi, Hamada, Yoji, Nakashima, Eitaro, Kamiya, Hideki, Hata, Masaki, Nishikawa, Toru, Enomoto, Atsushi, Takahashi, Masahide, Murohara, Toyoaki, Matsubara, Tatsuaki, Oiso, Yutaka, Nakamura, Jiro
Format:	Online
Language:	English
Published:	Blackwell Publishing Ltd 2011
Online Access:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014965/

id	pubmed-4014965
recordtype	oai_dc
spelling	pubmed-40149652014-05-19 High glucose impairs the proliferation and increases the apoptosis of endothelial progenitor cells by suppression of Akt Nakamura, Nobuhisa Naruse, Keiko Kobayashi, Yasuko Matsuki, Takashi Hamada, Yoji Nakashima, Eitaro Kamiya, Hideki Hata, Masaki Nishikawa, Toru Enomoto, Atsushi Takahashi, Masahide Murohara, Toyoaki Matsubara, Tatsuaki Oiso, Yutaka Nakamura, Jiro Articles Aims/Introduction: Endothelial progenitor cells (EPC) play a critical role in adult vasculogenesis and vascular repair. Previous studies have described the dysfunction of EPC in diabetic patients, but the precise mechanism is still unclear. To elucidate the dysfunction of EPC in diabetic patients, we investigated the functions and intracellular signaling of EPC under normal or high glucose conditions. We also examined the number of EPC in the peripheral blood of Japanese type 2 diabetic patients. Blackwell Publishing Ltd 2011-08-02 2011-01-24 /pmc/articles/PMC4014965/ /pubmed/24843496 http://dx.doi.org/10.1111/j.2040-1124.2010.00093.x Text en © 2011 Asian Association for the Study of Diabetes and Blackwell Publishing Asia Pty Ltd
repository_type	Open Access Journal
institution_category	Foreign Institution
institution	US National Center for Biotechnology Information
building	NCBI PubMed
collection	Online Access
language	English
format	Online
author	Nakamura, Nobuhisa Naruse, Keiko Kobayashi, Yasuko Matsuki, Takashi Hamada, Yoji Nakashima, Eitaro Kamiya, Hideki Hata, Masaki Nishikawa, Toru Enomoto, Atsushi Takahashi, Masahide Murohara, Toyoaki Matsubara, Tatsuaki Oiso, Yutaka Nakamura, Jiro
spellingShingle	Nakamura, Nobuhisa Naruse, Keiko Kobayashi, Yasuko Matsuki, Takashi Hamada, Yoji Nakashima, Eitaro Kamiya, Hideki Hata, Masaki Nishikawa, Toru Enomoto, Atsushi Takahashi, Masahide Murohara, Toyoaki Matsubara, Tatsuaki Oiso, Yutaka Nakamura, Jiro High glucose impairs the proliferation and increases the apoptosis of endothelial progenitor cells by suppression of Akt
author_facet	Nakamura, Nobuhisa Naruse, Keiko Kobayashi, Yasuko Matsuki, Takashi Hamada, Yoji Nakashima, Eitaro Kamiya, Hideki Hata, Masaki Nishikawa, Toru Enomoto, Atsushi Takahashi, Masahide Murohara, Toyoaki Matsubara, Tatsuaki Oiso, Yutaka Nakamura, Jiro
author_sort	Nakamura, Nobuhisa
title	High glucose impairs the proliferation and increases the apoptosis of endothelial progenitor cells by suppression of Akt
title_short	High glucose impairs the proliferation and increases the apoptosis of endothelial progenitor cells by suppression of Akt
title_full	High glucose impairs the proliferation and increases the apoptosis of endothelial progenitor cells by suppression of Akt
title_fullStr	High glucose impairs the proliferation and increases the apoptosis of endothelial progenitor cells by suppression of Akt
title_full_unstemmed	High glucose impairs the proliferation and increases the apoptosis of endothelial progenitor cells by suppression of Akt
title_sort	high glucose impairs the proliferation and increases the apoptosis of endothelial progenitor cells by suppression of akt
description	Aims/Introduction: Endothelial progenitor cells (EPC) play a critical role in adult vasculogenesis and vascular repair. Previous studies have described the dysfunction of EPC in diabetic patients, but the precise mechanism is still unclear. To elucidate the dysfunction of EPC in diabetic patients, we investigated the functions and intracellular signaling of EPC under normal or high glucose conditions. We also examined the number of EPC in the peripheral blood of Japanese type 2 diabetic patients.
publisher	Blackwell Publishing Ltd
publishDate	2011
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014965/
_version_	1612086959322169344

High glucose impairs the proliferation and increases the apoptosis of endothelial progenitor cells by suppression of Akt

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