Protein Tyrosine Phosphatases PTP-1B, SHP-2, and PTEN Facilitate Rb/E2F-Associated Apoptotic Signaling

Protein Tyrosine Phosphatases PTP-1B, SHP-2, and PTEN Facilitate Rb/E2F-Associated Apoptotic Signaling

To maintain tissue homeostasis, apoptosis is functionally linked to the cell cycle through the retinoblastoma (Rb)/E2F pathway. When the Rb tumor suppressor protein is functionally inactivated, E2F1 elicits an apoptotic response through both intrinsic (caspase-9 mediated) and extrinsic (caspase-8 me...

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Bibliographic Details
Main Authors: Morales, Liza D., Casillas Pavón, Edgar A., Shin, Jun Wan, Garcia, Alexander, Capetillo, Mario, Kim, Dae Joon, Lieman, Jonathan H.
Format: Online
Language:English
Published: Public Library of Science 2014
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014576/

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4014576/

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